Involvement of Viral Infections in the Pathogenesis of Chronic Lymphocytic Thyroiditis

Completed

• Conditions: Autoimmune Diseases; Chronic Lymphocytic Thyroiditis
• Interventions: Other: Comparison of the prevalences of the parvovirus genome

• Registration Number: NCT03114267
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

Autoimmune diseases represent a heterogeneous group of pathologies whose etiopathogenic mechanisms are most often unknown. Autoimmune diseases are the leading cause of morbidity and mortality in young women and autoimmune thyroid diseases are the most common.

Viral infections are the main environmental factors suspected of triggering autoimmune diseases. Several viruses are certainly involved, all of which are possibly capable of triggering an autoimmune response. However, the precise identification of the viruses involved remains to be established.

It has been shown for the first time by the 2005 PHRC that enteroviral RNA is present in perioperative specimens of thyroid tissue. However, this case-control study did not show any difference between the thyroid group and the group other thyroid pathologies It has been recently published that Parvovirus is possibly involved in thyroiditis: the parvoviral genome is present in the thyroid tissue of Hashimoto thyroiditis operated and more precisely is present within the thyrocytes itself.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01-06
• Primary Completion: 2015-01-06
• Study Completion: 2015-01-06
• Status Verified: 2017-04
• Study First Submitted: 2017-04-11
• Study First Submitted QC: 2017-04-11
• Last Update Submitted: 2017-04-11
• Study First Posted: 2017-04-14
• Last Update Posted: 2017-04-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

• Patients participating in PHRC 2005 "involvement of enteroviruses in TLC pathogenesis"
• Inclusion of TLC: presence of a significant lymphocyte infiltrate within the thyroid parenchyma defined by the presence of clusters of more than 30 to 50 lymphocytes
• Inclusion of controls: absence of significant lymphocyte infiltrate

Exclusion Criteria

• Persons refusing to participate in research

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Healthy subjects	Comparison of the prevalences of the parvovirus genome	-
Patient with chronic lymphocytic thyroiditis	Comparison of the prevalences of the parvovirus genome	-

Primary Outcome Measures

Name	Time	Method
Analysis of the viral genome by PCR carried out in the Virology department, Analysis of the presence of capsid protein	1 day

Trial Locations

Locations (1)

CHU Amiens Picardie; 🇫🇷 Amiens, Picardie, France