Acoustic Radiation Force Impulse Imaging (ARFI) based shear wave elastography in renal transplantatio

Not Applicable

• Conditions: Status post kidney transplantation; Z94.0; Kidney transplant status

• Registration Number: DRKS00011425
• Lead Sponsor: Klinik für Innere Medizin 1, Universitätsklinik Ulm

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2016-12-19
• Study Completion: 2019-04-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

• Kidney transplant recipients with follow up in renal outpatient clinic in Universities of Ulm and Mannheim.

• Age = 18 yrs

• Written informed consent for study participation

Exclusion Criteria

• Severe neurological or psychiatric disorders influencing with study consent

• Missing consent for study participation

• Anatomical characteristics interfering with the elastographic measurement

• Contraindications for ultrasonographic testing

• Pregnancy

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Allograft function (estimated by EKD-EPI GFR) baseline and after 3, 6, 9 and 12 months and shear wave velocity (in m/s) determined by ARFI based elastography at baseline and after 6 and 12 months.

Secondary Outcome Measures

Name	Time	Method
Proteinuria and urinary biomarkers associated with acute and chronic kidney injury (Neutrophil-Gelatinase-Associated Lipocalin (NGAL), Clusterin, Interleukin (IL) -18, Kidney Injury Molecule (KIM) -1, complement factors C3a, C5a and terminal complement complex) (Month 0, 3, 6, 9 and 12)<br>