Inflammatory Responses After CrossFit and Resistance Trainings in Untrained Subjects

Not Applicable

Completed

• Conditions: Inflammation; Oxidative Stress; Plasma Volume; Hormones

• Registration Number: NCT07190924
• Lead Sponsor: Habil Hamdouni

Brief Summary

Considering the remarkable increase of the fitness programs, the purpose of this study was to assess and compare the effect of Crossfit (CF) and periodized resistance (RT) trainings on inflammatory/oxidative responses in untrained individuals.

Twenty-four participants (20 men and 4 women, age= 25.7 ± 2.2 years, BMI= 25.7 kg.m-2) were randomly assigned into 12 weeks of these trainings with a rate of five sessions/week. Before and after intervention, participants anthropometric data and graded exercise tests were performed. Before (pre), immediately after (post) and 60min after test (p60) a 20mL venous blood sample were drawn for a later measure of c-reactive protein (CRP), interleukin 1 beta (IL-1ß), tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), interleukin 10 (IL-10), thiobarbituric acid reactive substances (TBARS), antioxidant enzymes catalase (CAT) and glutathione peroxidase (GPx).

Detailed Description

Not available

Study Timeline

• Study Start: 2021-11-08
• Primary Completion: 2022-02-08
• Study Completion: 2022-04-17
• Status Verified: 2025-09
• Study First Submitted: 2025-09-14
• Study First Submitted QC: 2025-09-18
• Last Update Submitted: 2025-09-18
• Study First Posted: 2025-09-24
• Last Update Posted: 2025-09-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Participants must be non-smokers,
• Participants should not suffer from respiratory issues
• Participants should have healthy kidney and liver
• Participants have no metabolic and neurological disorders

Exclusion Criteria

• The use of medications during the previous 4 weeks
• Consumption of any product related to anti-inflammatory/oxidative supplements

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Inflammatory marker	Participants data were performed in one day before beginning the 12 week intervention and one day after the last session	interleukin 10 (IL-10)
Oxidative stress	Participants data were performed in one day before beginning the 12 week intervention and one day after the last session	glutathione peroxidase (GPx)

Trial Locations

Locations (1)

Institut Supérieur du Sport et de l'Education Physique de Ksar-Saïd; 🇹🇳 Aryanah, Ariana Governorate, Tunisia