An Investigational Immuno-therapy Trial of Nivolumab, or Nivolumab Plus Ipilimumab, or Nivolumab Plus Platinum-doublet Chemotherapy, Compared to Platinum Doublet Chemotherapy in Patients With Stage IV Non-Small Cell Lung Cancer (NSCLC)
- Conditions
- Non-Small Cell Lung Cancer
- Interventions
- Registration Number
- NCT02477826
- Lead Sponsor
- Bristol-Myers Squibb
- Brief Summary
The purpose of this study is to show that Nivolumab, or Nivolumab plus Ipilimumab, or Nivolumab plus Platinum-Doublet Chemotherapy improves progression free survival and/or overall survival compared with chemotherapy in patients with advanced lung cancer.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 2748
- Subjects with histologically confirmed Stage IV or recurrent NSCLC squamous or non-squamous histology, with no prior systemic anticancer therapy
- Subjects must have programmed death-ligand 1 (PD -L1) immunohistochemical (IHC) testing, with results, performed by the central lab during the Screening period
- Eastern Cooperative Oncology Group (ECOG) Performance Status of ≤ 1
- Measurable disease by CT or MRI per response evaluation criteria in solid tumors version 1.1 (RECIST 1.1) criteria
- Subjects with untreated Central nervous system (CNS) metastases are excluded
- Subjects with an active, known or suspected autoimmune disease are excluded
- Any positive test for hepatitis B virus or hepatitis C virus or human immunodeficiency virus (HIV) indicating acute or chronic infection
Other protocol defined inclusion/exclusion criteria apply
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Arm B: Nivolumab + Ipilimumab Ipilimumab Nivolumab + Ipilimumab IV as specified Arm D: Platinum doublet chemotherapy Gemcitabine Chemotherapy administered on specified days of IV chemotherapy Arm D: Platinum doublet chemotherapy Paclitaxel Chemotherapy administered on specified days of IV chemotherapy Arm A: Nivolumab Nivolumab Nivolumab intravenously (IV) as specified Arm C: Nivolumab + Platinum doublet chemotherapy Nivolumab Nivolumab + Platinum doublet chemotherapy (IV) dose as specified Arm D: Platinum doublet chemotherapy Carboplatin Chemotherapy administered on specified days of IV chemotherapy Arm D: Platinum doublet chemotherapy Pemetrexed Chemotherapy administered on specified days of IV chemotherapy Arm C: Nivolumab + Platinum doublet chemotherapy Paclitaxel Nivolumab + Platinum doublet chemotherapy (IV) dose as specified Arm B: Nivolumab + Ipilimumab Nivolumab Nivolumab + Ipilimumab IV as specified Arm C: Nivolumab + Platinum doublet chemotherapy Cisplatin Nivolumab + Platinum doublet chemotherapy (IV) dose as specified Arm C: Nivolumab + Platinum doublet chemotherapy Carboplatin Nivolumab + Platinum doublet chemotherapy (IV) dose as specified Arm C: Nivolumab + Platinum doublet chemotherapy Gemcitabine Nivolumab + Platinum doublet chemotherapy (IV) dose as specified Arm C: Nivolumab + Platinum doublet chemotherapy Pemetrexed Nivolumab + Platinum doublet chemotherapy (IV) dose as specified Arm D: Platinum doublet chemotherapy Cisplatin Chemotherapy administered on specified days of IV chemotherapy
- Primary Outcome Measures
Name Time Method Overall survival (OS) approximately 48 months Progression-free Survival (PFS) as determined by blinded independent central review (BICR) approximately 40 months
- Secondary Outcome Measures
Name Time Method Disease related symptom improvement as measured by the Lung Cancer Symptom Score (LCSS) in all subjects Up to 48 months Disease related symptom improvement assessed at each dosing for 6 months, then every 6 weeks while on treatment
Objective response rate (ORR) Up to 48 months ORR of nivolumab monotherapy and nivolumab in combination with ipilimumab to platinum-doublet chemotherapy in subjects with advanced lung cancer
Trial Locations
- Locations (290)
Local Institution - 0017
🇺🇸San Francisco, California, United States
Local Institution - 0115
🇺🇸Saint Louis, Missouri, United States
Local Institution - 0014
🇺🇸Cleveland, Ohio, United States
Local Institution - 0075
🇺🇸Langhorne, Pennsylvania, United States
Local Institution - 0083
🇮🇹Milan, Lombardia, Italy
Local Institution - 0179
🇮🇹Bergamo, Italy
Local Institution - 0087
🇮🇹Perugia, Italy
Local Institution - 0085
🇮🇹Terni, Italy
Southern Cancer Center, Inc.
🇺🇸Mobile, Alabama, United States
Local Institution - 0021
🇺🇸New Haven, Connecticut, United States
Local Institution - 0001
🇺🇸Atlanta, Georgia, United States
Local Institution - 0013
🇺🇸Marietta, Georgia, United States
Local Institution - 0004
🇺🇸Lexington, Kentucky, United States
Local Institution - 0005
🇺🇸Buffalo, New York, United States
Local Institution - 0019
🇺🇸New York, New York, United States
Local Institution - 0009
🇺🇸Columbus, Ohio, United States
Local Institution - 0007
🇺🇸Allentown, Pennsylvania, United States
Local Institution - 0299
🇺🇸Philadelphia, Pennsylvania, United States
Local Institution - 0012
🇺🇸Philadelphia, Pennsylvania, United States
Local Institution - 0015
🇺🇸Sayre, Pennsylvania, United States
Local Institution - 0008
🇺🇸Charleston, South Carolina, United States
Local Institution - 0080
🇺🇸Greenville, South Carolina, United States
Local Institution - 0306
🇺🇸Dallas, Texas, United States
Local Institution - 0003
🇺🇸Dallas, Texas, United States
Local Institution - 0010
🇺🇸Greenville, South Carolina, United States
Local Institution - 0020
🇺🇸Nashville, Tennessee, United States
Local Institution - 0102
🇺🇸Houston, Texas, United States
Local Institution - 0011
🇺🇸Salt Lake City, Utah, United States
Local Institution - 0074
🇺🇸Kennewick, Washington, United States
Local Institution - 0170
🇦🇷Berazategui, Buenos Aires, Argentina
Local Institution - 0171
🇦🇷Capital Federal, Buenos Aires, Argentina
Local Institution - 0172
🇦🇷Ciudad Autonoma De Buenos Aire, Buenos Aires, Argentina
Local Institution - 0176
🇦🇷Ciudad de Buenos Aires, Buenos Aires, Argentina
Local Institution - 0296
🇦🇷Mar Del Plata, Buenos Aires, Argentina
Local Institution - 0177
🇦🇷Viedma, RIO Negro, Argentina
Local Institution - 0130
🇦🇷San Miguel de Tucuman, Tucuman, Argentina
Local Institution - 0268
🇦🇷Cordoba, Argentina
Local Institution - 0272
🇦🇷Córdoba, Argentina
Local Institution - 0297
🇦🇷Córdoba, Argentina
Local Institution - 0182
🇦🇺Garran, Australian Capital Territory, Australia
Local Institution - 0301
🇦🇺Blacktown, New South Wales, Australia
Local Institution - 0300
🇦🇺Gosford, New South Wales, Australia
Local Institution - 0045
🇦🇺Brisbane, Queensland, Australia
Local Institution - 0046
🇦🇺Elizabeth Vale, South Australia, Australia
Local Institution - 0043
🇦🇺Clayton, Victoria, Australia
Local Institution - 0042
🇦🇺Fitzroy, Victoria, Australia
Local Institution - 0180
🇦🇺Perth, Western Australia, Australia
Local Institution - 0040
🇦🇺Murdoch, Australia
Local Institution - 0183
🇦🇺North Tamworth, Australia
Local Institution - 0241
🇦🇹Graz, Austria
Local Institution - 0240
🇦🇹Vienna, Austria
Local Institution - 0239
🇦🇹Wels, Austria
Local Institution - 0121
🇧🇪Roeselare, West-Vlaanderen, Belgium
Local Institution - 0030
🇧🇪Edegem, Belgium
Local Institution - 0031
🇧🇪Gent, Belgium
Local Institution - 0034
🇧🇪Gilly, Belgium
Local Institution - 0117
🇧🇪Hasselt, Belgium
Local Institution - 0033
🇧🇪Sint Niklaas, Belgium
Local Institution - 0125
🇧🇷Salvador, Bahia, Brazil
Local Institution - 0124
🇧🇷Ijui, RIO Grande DO SUL, Brazil
Local Institution - 0123
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Local Institution - 0127
🇧🇷Barretos, Sao Paulo, Brazil
Local Institution - 0129
🇧🇷Rio De Janeiro, Brazil
Local Institution - 0144
🇧🇷Sao Paulo, Brazil
Local Institution - 0126
🇧🇷Sao Paulo, Brazil
Local Institution - 0128
🇧🇷Sao Paulo, Brazil
Local Institution - 0103
🇨🇦Edmonton, Alberta, Canada
Local Institution - 0290
🇨🇦St. John's, Newfoundland and Labrador, Canada
Local Institution - 0104
🇨🇦London, Ontario, Canada
Local Institution - 0122
🇨🇦Montreal, Quebec, Canada
Local Institution - 0106
🇨🇦Quebec City, Quebec, Canada
Local Institution - 0107
🇨🇦Rimouski, Quebec, Canada
Local Institution - 0291
🇨🇦Sherbrooke, Quebec, Canada
Local Institution - 0292
🇨🇦Trois-Rivieres, Quebec, Canada
Local Institution - 0302
🇨🇦Quebec, Canada
Local Institution - 0173
🇨🇱Santiago, Metropolitana, Chile
Local Institution - 0131
🇨🇱Santiago, Región Metropolitana De Santiago, Chile
Local Institution - 0174
🇨🇱Vina Del Mar, Valparaiso, Chile
Local Institution - 0380
🇨🇳Hefei, Anhui, China
Local Institution - 0313
🇨🇳Beijing, Beijing, China
Local Institution - 0315
🇨🇳Beijing, Beijing, China
Local Institution - 0316
🇨🇳Beijing, Beijing, China
Local Institution - 0314
🇨🇳Beijing, Beijing, China
Local Institution - 0365
🇨🇳Chongqing, Chongqing, China
Local Institution - 0364
🇨🇳Chongqing, Chongqing, China
Local Institution - 0378
🇨🇳Chongqing, Chongqing, China
Local Institution - 0322
🇨🇳Guangzhou, Guangdong, China
Local Institution - 0372
🇨🇳Guangzhou, Guangdong, China
Local Institution - 0319
🇨🇳Guanzhou, Guangdong, China
Local Institution - 0323
🇨🇳Haikou, Hainan, China
Local Institution - 0325
🇨🇳Haerbin, Heilongjiang, China
Local Institution - 0324
🇨🇳Zhengzhou, Henan, China
Local Institution - 0379
🇨🇳Zhengzhou, Henan, China
Local Institution - 0375
🇨🇳Wuhan, Hubei, China
Local Institution - 0362
🇨🇳Changsha, Hunan, China
Local Institution - 0347
🇨🇳Nanchang, Jiangxi, China
Local Institution - 0329
🇨🇳Changchun, Jilin, China
Local Institution - 0361
🇨🇳Changchun, Jilin, China
Local Institution - 0359
🇨🇳Shenyang, Liaoning, China
Local Institution - 0371
🇨🇳Xi'an, Shaanxi, China
Local Institution - 0333
🇨🇳Xi'an, Shan3xi, China
Local Institution - 0360
🇨🇳Qingdao, Shandong, China
Local Institution - 0334
🇨🇳Shanghai, Shanghai, China
Local Institution - 0373
🇨🇳Tianjin, Tianjin, China
Local Institution - 0376
🇨🇳Chengdu, Sichuan, China
Local Institution - 0340
🇨🇳Urumqi, Xinjiang, China
Local Institution - 0343
🇨🇳Hangzhou, Zhejiang, China
Local Institution - 0342
🇨🇳Hangzhou, Zhejiang, China
Local Institution - 0370
🇨🇳Hangzhou, Zhejiang, China
Local Institution - 0328
🇨🇳Changsha, China
Local Institution - 0341
🇨🇳Hangzhou, China
Local Institution - 0345
🇨🇳Kunming, China
Local Institution - 0336
🇨🇳Shanghai, China
Local Institution - 0337
🇨🇳Shanghai, China
Local Institution - 0374
🇨🇳Shantou, China
Local Institution - 0273
🇨🇴Pereira, Risaralda, Colombia
Local Institution - 0237
🇨🇴Bogota, Colombia
Local Institution - 0238
🇨🇴Bogota, Colombia
Local Institution - 0282
🇨🇴Medellin, Colombia
Local Institution - 0112
🇨🇿Hradec Kralove, Czechia
Local Institution - 0113
🇨🇿Olomouc, Czechia
Local Institution - 0111
🇨🇿Praha 4, Czechia
Local Institution - 0232
🇨🇿Pribram, Czechia
Local Institution - 0270
🇫🇮Oulu, Finland
Local Institution - 0271
🇫🇮Turku, Finland
Local Institution - 0222
🇫🇷Bron, Rhône, France
Local Institution - 0216
🇫🇷ANGERS Cedex 2, France
Local Institution - 0229
🇫🇷Besançon Cedex, France
Local Institution - 0283
🇫🇷Caen, France
Local Institution - 0218
🇫🇷Creteil, France
Local Institution - 0228
🇫🇷Limoges, France
Local Institution - 0230
🇫🇷Paris, France
Local Institution - 0215
🇫🇷Marseille Cedex 20, France
Local Institution - 0227
🇫🇷Pessac, France
Local Institution - 0223
🇫🇷Rennes, France
Local Institution - 0225
🇫🇷Rouen, France
Local Institution - 0221
🇫🇷Saint Priest En Jarez, France
Local Institution - 0217
🇫🇷Saint-herblain Cedex, France
Local Institution - 0224
🇫🇷Strasbourg, France
Local Institution - 0226
🇫🇷Toulon, France
Local Institution - 0231
🇩🇪Magdeburg, Sachsen-Anhalt, Germany
Local Institution - 0213
🇩🇪Bad Berka, Germany
Local Institution - 0208
🇩🇪Berlin, Germany
Local Institution - 0205
🇩🇪Essen, Germany
Local Institution - 0210
🇩🇪Frankfurt, Germany
Local Institution - 0211
🇩🇪Gera, Germany
Local Institution - 0203
🇩🇪Grosshansdorf, Germany
Local Institution - 0209
🇩🇪Halle, Germany
Local Institution - 0202
🇩🇪Heidelberg, Germany
Local Institution - 0214
🇩🇪Hemer, Germany
Local Institution - 0206
🇩🇪Immenstadt, Germany
Local Institution - 0204
🇩🇪Muenchen, Germany
Local Institution - 0201
🇩🇪Stuttgart, Germany
Local Institution - 0212
🇩🇪Wiesbaden, Germany
Local Institution - 0094
🇬🇷Athens, Attikí, Greece
Local Institution - 0095
🇬🇷Heraklion, Greece
Local Institution - 0190
🇬🇷Neo Faliro, Greece
Local Institution - 0101
🇬🇷Thessaloniki, Greece
Local Institution - 0025
🇭🇺Budapest, Hungary
Local Institution - 0024
🇭🇺Budapest, Hungary
Local Institution - 0026
🇭🇺Matrahaza, Hungary
Local Institution - 0054
🇮🇪Dublin 8, Dublin, Ireland
Local Institution - 0053
🇮🇪Beaumont, Ireland
Local Institution - 0055
🇮🇪Galway, Ireland
Local Institution - 0100
🇮🇪Limerick, Ireland
Local Institution - 0187
🇮🇱Jerusalem, Israel
Local Institution - 0186
🇮🇱Kfar-saba, Israel
Local Institution - 0185
🇮🇱Petach Tikva, Israel
Local Institution - 0184
🇮🇱Tel-hashomer, Israel
Local Institution - 0188
🇮🇱Zerifin, Israel
Azienda Ospedaliera Moscati
🇮🇹Avellino, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
🇮🇹Bologna, Italy
Local Institution - 0084
🇮🇹Livorno, Italy
Policlinico G. Martino
🇮🇹Messina, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
🇮🇹Milan, Italy
Istituto Nazionale Tumori Fondazione Pascale
🇮🇹Napoli, Italy
Ospedale Santa Maria delle Croci
🇮🇹Ravenna, Italy
Ifo-Istituto Regina Elena
🇮🇹Roma, Italy
Local Institution - 0089
🇮🇹Roma, Italy
Local Institution - 0153
🇯🇵Nagoya-shi, Aichi, Japan
Local Institution - 0152
🇯🇵Nagoya, Aichi, Japan
Local Institution - 0148
🇯🇵Kashiwa-shi, Chiba, Japan
Local Institution - 0159
🇯🇵Matsuyama, Ehime, Japan
Local Institution - 0160
🇯🇵Fukuoka-shi, Fukuoka, Japan
Local Institution - 0259
🇯🇵Kurume-shi, Fukuoka, Japan
Local Institution - 0255
🇯🇵Ota-shi, Gunma, Japan
Local Institution - 0258
🇯🇵Hiroshima-shi, Hiroshima, Japan
Local Institution - 0163
🇯🇵Sapporo-shi, Hokkaido, Japan
Local Institution - 0253
🇯🇵Sapporo-shi, Hokkaido, Japan
Local Institution - 0252
🇯🇵Akashi-shi, Hyogo, Japan
Local Institution - 0156
🇯🇵Kobe-shi, Hyogo, Japan
Local Institution - 0146
🇯🇵Kanazawa-shi, Ishikawa, Japan
Local Institution - 0161
🇯🇵Yokohama-shi, Kanagawa, Japan
Local Institution - 0150
🇯🇵Yokohama-Shi, Kanagawa, Japan
Local Institution - 0275
🇯🇵Natori-shi, Miyagi, Japan
Local Institution - 0254
🇯🇵Sendai-shi, Miyagi, Japan
Local Institution - 0145
🇯🇵Sendai-shi, Miyagi, Japan
Local Institution - 0164
🇯🇵Niigata-shi, Niigata, Japan
Local Institution - 0158
🇯🇵Kurashiki-shi, Okayama, Japan
Local Institution - 0155
🇯🇵Hirakata-shi, Osaka, Japan
Local Institution - 0154
🇯🇵Osaka-shi, Osaka, Japan
Local Institution - 0251
🇯🇵Osakasayama-shi, Osaka, Japan
Local Institution - 0257
🇯🇵Takatsuki-shi, Osaka, Japan
Local Institution - 0353
🇯🇵Hidaka-shi, Saitama, Japan
Local Institution - 0256
🇯🇵Kitaadachi-gun, Saitama, Japan
Local Institution - 0151
🇯🇵Sunto-gun, Shizuoka, Japan
Local Institution - 0147
🇯🇵Chuo-ku, Tokyo, Japan
Local Institution - 0149
🇯🇵Koto-ku, Tokyo, Japan
Local Institution - 0278
🇯🇵Shinjuku-ku, Tokyo, Japan
Local Institution - 0157
🇯🇵Wakayama-shi, Wakayama, Japan
Local Institution - 0354
🇯🇵Ube-shi, Yamaguchi, Japan
Local Institution - 0260
🇯🇵Chiba, Japan
Local Institution - 0165
🇯🇵Okayama, Japan
Local Institution - 0162
🇯🇵Tokyo, Japan
Local Institution - 0136
🇰🇷Seongnam-si, Kyǒnggi-do, Korea, Republic of
Local Institution - 0249
🇰🇷Cheongju-si, Korea, Republic of
Local Institution - 0133
🇰🇷Gangnam-gu, Korea, Republic of
Local Institution - 0132
🇰🇷Seoul, Korea, Republic of
Local Institution - 0135
🇰🇷Seoul, Korea, Republic of
Local Institution - 0287
🇱🇧Beirut, Lebanon
Local Institution - 0286
🇱🇧Beirut, Lebanon
Local Institution - 0196
🇲🇽Df, Distrito Federal, Mexico
Local Institution - 0193
🇲🇽Mexico, Distrito Federal, Mexico
Local Institution - 0198
🇲🇽Cuautitlan, Estado DE Mexico, Mexico
Local Institution - 0197
🇲🇽Guadalajara, Jalisco, Mexico
Local Institution - 0191
🇲🇽Zapopan, Jalisco, Mexico
Local Institution - 0267
🇲🇽Morelia, Michoacan, Mexico
Local Institution - 0277
🇲🇽Monterrey, Nuevo Leon, Mexico
Local Institution - 0303
🇲🇽Merida, Yucatán, Mexico
Local Institution - 0192
🇲🇽Chihuahua, Mexico
Local Institution - 0195
🇲🇽San Luis Potosi, Mexico
Local Institution - 0236
🇲🇽San Luis Potosi, Mexico
Local Institution - 0194
🇲🇽Toluca, Mexico
Local Institution - 0036
🇳🇱Amsterdam, Netherlands
Local Institution - 0189
🇳🇱Amsterdam, Netherlands
Local Institution - 0169
🇳🇱Breda, Netherlands
Local Institution - 0037
🇳🇱Rotterdam, Netherlands
Local Institution - 0039
🇳🇱Veldhoven, Netherlands
Local Institution - 0262
🇵🇪Lima, Peru
Local Institution - 0263
🇵🇪Lima, Peru
Local Institution - 0350
🇵🇪Lima, Peru
Local Institution - 0261
🇵🇪Lima, Peru
Local Institution - 0351
🇵🇪Lima, Peru
Local Institution - 0060
🇵🇱Bydgoszcz, Poland
Local Institution - 0058
🇵🇱Gdansk, Poland
Local Institution - 0063
🇵🇱Gdynia, Poland
Local Institution - 0072
🇵🇱Gliwice, Poland
Local Institution - 0057
🇵🇱Lodz, Poland
Local Institution - 0059
🇵🇱Warszawa, Poland
Local Institution - 0070
🇵🇱Wroclaw, Poland
Local Institution - 0167
🇷🇴Craiova, Romania
Local Institution - 0250
🇷🇴Floresti, Romania
Local Institution - 0166
🇷🇴Romania, Romania
Local Institution - 0284
🇷🇴Sector 2, Romania
Local Institution - 0137
🇷🇺Chelyabinsk, Russian Federation
Local Institution - 0142
🇷🇺Kazan, Russian Federation
Local Institution - 0022
🇷🇺Moscow, Russian Federation
Local Institution - 0049
🇷🇺Saint-Petersburg, Russian Federation
Local Institution - 0028
🇷🇺St. Petersburg, Russian Federation
Local Institution - 0027
🇷🇺St. Petersburg, Russian Federation
Local Institution - 0143
🇷🇺Ufa, Russian Federation
Local Institution - 0264
🇿🇦Pretoria, Gauteng, South Africa
Local Institution - 0234
🇿🇦Sandton, Gauteng, South Africa
Local Institution - 0233
🇿🇦Saxonwold, Johannesburg, Gauteng, South Africa
Local Institution - 0305
🇿🇦Vereeniging, South Africa
Local Institution - 0064
🇪🇸Majadahonda, Madrid, Spain
Local Institution - 0066
🇪🇸Barcelona, Spain
Local Institution - 0067
🇪🇸Barcelona, Spain
Local Institution - 0065
🇪🇸Madrid, Spain
Local Institution - 0068
🇪🇸Valencia, Spain
Local Institution - 0069
🇪🇸Sevilla, Spain
Local Institution - 0243
🇨🇭Basel, Switzerland
Local Institution - 0246
🇨🇭Chur, Switzerland
Local Institution - 0244
🇨🇭Lausanne, Switzerland
Local Institution - 0245
🇨🇭Winterthur, Switzerland
Local Institution - 0139
🇨🇳Taichung, Taiwan
Local Institution - 0138
🇨🇳Taipei, Taiwan
Local Institution - 0140
🇨🇳Taipei, Taiwan
Local Institution - 0310
🇨🇳Taipei, Taiwan
Local Institution - 0141
🇨🇳Taoyuan city, Taiwan
Local Institution - 0266
🇬🇧Middlesborough, Cleveland, United Kingdom
Local Institution - 0098
🇬🇧London, Greater London, United Kingdom
Local Institution - 0099
🇬🇧Southampton, Hampshire, United Kingdom
Local Institution - 0118
🇬🇧Leicester, Leicestershire, United Kingdom
Local Institution - 0265
🇬🇧Birmingham, United Kingdom
Local Institution - 0051
🇬🇧Cambridgeshire, United Kingdom
Local Institution - 0109
🇬🇧Edinburgh, United Kingdom
Local Institution - 0097
🇬🇧London, United Kingdom
Local Institution - 0050
🇬🇧London, United Kingdom
Local Institution - 0119
🇬🇧Surrey, United Kingdom