The acute effects of flavonoid-rich apples and nitrate-rich vegetables on nitric oxide status, blood pressure, endothelial function and cognitive function in healthy men and wome

Not Applicable

Completed

• Conditions: Cardiovascular - Coronary heart disease; Cognitive function; Diet and Nutrition - Other diet and nutrition disorders; Cardiovascular disease; Cardiovascular - Hypertension

• Registration Number: ACTRN12609000425291
• Lead Sponsor: niversity of Western Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-06-10
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

Men and women aged 18 to 65 years

Exclusion Criteria

1. Current or recent (<12 months) smoking
2. Body mass index < 18 or > 35 kg/m2
3. History of cardiovascular or peripheral vascular disease
4. A systolic blood pressure below 100 or above 160 mmHg
5. A diastolic blood pressure below 50 or above 100 mmHg
6. diagnosed diabetes, and non-diabetic individuals with fasting plasma glucose concentrations greater than or equal to 5.5 mmol/L
7. A psychiatric illness
8. other major illnesses such as cancer
9. Current or recent (within previous 6 months) significant weight loss or gain (> 6% of body weight)
10. Reported lactating, pregnant or wishing to become pregnant during the study
11. Alcohol intake > 210 g per wk for women and > 280 g per wk for men
12. Inability or unwillingness to consume foods/beverages provided
13. Deformities of fingers
14. Unwillingness to have short nails on testing days
15. Unwillingness to stop the use of supplements with nitrates or bioflavonoids during the testing period
16. Not willing to give up the use of mouth wash from one week prior to the testing period to the end of the testing period

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
itric oxide status assessed by measuring plasma S-nitrosothiols[2.5 hours after lunch]

Secondary Outcome Measures

Name	Time	Method
Plasma, urinary and salivary nitrate and nitrite concentrations[Plasma measurements performed at 2.5 hours after lunch.<br>Urinary measurements performed in a single 8 hour urine collection. (This is a single 8 hour urine collection which begins just prior to the breakfast meal and is completed late afternoon. The collection is a pooled collection so that individual spot urine sampels will not be analysed separately.)<br><br>Salivary measurements performed at 1.5 hours after lunch.];Blood pressure measured using an automated blood pressure monitor[mean blood pressure measured every 20-30 min post lunch for 5 hours];Endothelial function assessed by measuring flow-mediated dilatation of the brachial artery using ultrasound; and by measuring peripheral arterial tone using the Endo-PAT 2000.[2 to 2.5 hours post lunch];Cognitive function assessed using the Cognitive Drug Research computerized measure of cognition[3 hours after lunch]