Agility Training on Physical Performance, Cognitive Function and Brain Activities in Elderly

Not Applicable

• Conditions: Healthy; Elderly
• Interventions: Other: Agility Training; Other: Health Education

• Registration Number: NCT05531396
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

Agility comprised of cognitive and physical functions, which influences whole-body movement with change of speed and direction. Agility training is widely used in athletes, and recent studies have begun to apply it into the elderly. Agility training is multidimensional and highly functional, which makes it possible to provide more efficient training in limited time. In elderly, the decrement of cognitive function, muscle strength in the upper and lower limbs, the percentage of body fat, body flexibility and endurance caused by aging will make it difficult for the elderly to perform movements. Therefore, it is essential to explore whether agility training can achieve the improvement of the physical function and cognitive function in elderly, and to find the relationship between the two functions and brain activity. Method: This study will recruit 60 participants, and randomly allocate to control group and agility training. The training groups will have 8 weeks of training, 2 times a week, 45 minutes of training each time. Assessment will be performed before and after intervention in 1-week, and with 1-month follow-up. Assessment including agility ability, physical function, cognitive function, brain activity, and functional assessment scales.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design

Study Timeline

• Status Verified: 2022-05
• Study First Submitted: 2022-08-05
• Study Start: 2022-09-05
• Study First Submitted QC: 2022-09-05
• Last Update Submitted: 2022-09-05
• Study First Posted: 2022-09-08
• Last Update Posted: 2022-09-08
• Primary Completion: 2023-05-23
• Study Completion: 2023-06-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. older than 65 years old
2. score of Mini-Mental State Examination (MMSE) ≥ 24
3. able to walk independently for more than 30 meters without assistive aids
4. able to follow orders

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Exclusion Criteria

1. poorly controlled or unstable systematic disease
2. has a history of central nervous system disease
3. currently taking antidepressants, anti-anxiety, or other psychiatric drugs that may affect blood flow in the brain
4. has other medical conditions for which exercise is contraindicated; (5) subjects with achromatopsia.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Agility Training Group	Agility Training	-
Health Education	Health Education	-

Primary Outcome Measures

Name	Time	Method
Agility Challenge for the Elderly (ACE)	Baseline, 8 weeks, and 12 weeks	An agility course developed for a 9m x 18m volleyball court and includes three segments that each aim to test a specific aspect of agility, including stop-and-go, change of direction, and spatial orientation.

Secondary Outcome Measures

Name	Time	Method
Fall history and fear of falls	Baseline, 8 weeks, and 12 weeks	Fall history will be recorded by the number of fall episodes in the past 6 months and whether it caused injury.
Brain activation	Baseline, 8 weeks, and 12 weeks	A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) will be used to detect the hemodynamics of brain areas associated with the agility test, cognitive tasks, and single and dual task walking test.
Quality of life (QOL)	Baseline, 8 weeks, and 12 weeks	Quality of life (QOL) will be evaluated by Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36).