Agility Training on Executive Function, Dual Task Performance and Brain Activation in Healthy Adults

Not Applicable

• Conditions: Agility Training; Executive Function
• Interventions: Other: Resistance+Aerobic training; Other: Agility training

• Registration Number: NCT04880057
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

This study will investigate the effect of agility training on executive function, dual task walking and brain activation in healthy adults. Participants (N=70) will be randomly assigned to resistance+aerobic training group (RAeT) or agility training group (AT). Participants in RAeT (n=35) will receive 15-minute lower extremity workout first and then 25-minute moderate intensity (60-75% predicted maximal heart rate) aerobic training. Participants in AT (n=35) will do the agility exercise program consisting of technical drills, pattern running and reactive agility training. The intervention will be twelve-time group intervention (3-5persons) in four weeks, 50 minutes per session (5-minute warmup, 40- minute main training, 5-minute cool-down). Participants will undergo three measurement time points (pre-, post-intervention and one month follow-up). Outcome measures will include executive function (N-back test, stroop test and Wisconsin card sort test), single and dual task walking performance and brain activity (fNIRS on prefrontal cortex, supplementary motor area and premotor cortex). Two-way analysis of variance (ANOVA) with Tukey post-hoc test will be used to examine the group x time interaction on three outcome measures.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-05-03
• Study First Submitted QC: 2021-05-06
• Study First Posted: 2021-05-10
• Study Start: 2021-08-02
• Status Verified: 2022-06
• Last Update Submitted: 2022-06-09
• Last Update Posted: 2022-06-13
• Primary Completion: 2022-12-31
• Study Completion: 2023-03-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• (1) age between 20 to 30 years, and (2) ability to walk 20 meters independently without an assistive device.

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Exclusion Criteria

• (1) overweight (BMI>24), (2) any smoker or alcohol abusers, (3) suffering from chronic diseases that loss of control, (4) Unstable physiological conditions, such as abnormal signs like high blood pressure, headache, dyspnea, fever, etc., (5) any neuromuscular or cardiopulmonary diseases that would influent the exercise performance, and (6) suffering from diseases which exercises are their contraindications

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Resistance+Aerobic training group	Resistance+Aerobic training	Resistance+Aerobic training group (RAeT) RAeT includes resistance training (RT) program and aerobic training (AeT) program.
Agility training group	Agility training	Agility training

Primary Outcome Measures

Name	Time	Method
Executive function- Stroop test	Change from Baseline score at 7 weeks	Stroop test is used to measure the selective attention and conflict resolution.
Single walking performance- Walking speed	Change from Baseline cadence at 7 weeks	The unit is length (cm) per seconds
Dual task walking performance- Stride length	Change from Baseline cadence at 7 weeks	The unit is cm
Dual task walking performance- Step duration	Change from Baseline cadence at 7 weeks	The unit is seconds
Executive function- Wisconsin card sort test	Change from Baseline score at 7 weeks	Wisconsin card sort test is an easy way to assess the ability of mental set shifting.
Single walking performance- Step duration	Change from Baseline cadence at 7 weeks	The unit is seconds
Dual task walking performance- Walking speed	Change from Baseline cadence at 7 weeks	The unit is length (cm) per seconds
Executive function- N-back task (3-back)	Change from Baseline score at 7 weeks	N-back task (3-back) is used to measure working memory
Single walking performance- Cadence	Change from Baseline cadence at 7 weeks	The unit is steps per minutes
Single walking performance- Stride length	Change from Baseline cadence at 7 weeks	The unit is cm
Dual task walking performance- Cadence	Change from Baseline cadence at 7 weeks	The unit is steps per minutes
Dual task walking performance- the correct rates of arithmetic task	Change from Baseline cadence at 7 weeks	The participants will be instructed to subtract by 7 serially from a 3-digit number while walking at their fastest speed in dual task walking condition

Secondary Outcome Measures

Name	Time	Method
Brain activities over supplementary motor area- Executive function	Change from Baseline at 7 weeks	A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
Brain activities over primary motor cortex - Single walking	Change from Baseline at 7 weeks	A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
Brain activities over primary motor cortex - Dual task walking	Change from Baseline at 7 weeks	A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
Brain activities over primary motor cortex- Executive function	Change from Baseline at 7 weeks	A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
Brain activities over premotor cortex- Single walking	Change from Baseline at 7 weeks	A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
Brain activities over supplementary motor area- Single walking	Change from Baseline at 7 weeks	A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
Brain activities over premotor cortex- Dual task walking	Change from Baseline at 7 weeks	A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
Brain activities over premotor cortex- Executive function	Change from Baseline at 7 weeks	A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
Brain activities over supplementary motor area- Dual task walking	Change from Baseline at 7 weeks	A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan