Krill Oil Supplementation and Its Effect on Intestinal Permeability Markers in Elite Rowers.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 主要终点
- I-FABP (intestinal fatty acid binding protein)
研究概览
简要总结
The study aims to check the influence of krill oil on markers of intestinal injury and intoxication.
Research group: the research will be conducted in a homogeneous group of professional rowers (N=30), all competitors qualified for the Polish Youth Rowing Team, aged 18 - 24. The sample size was confiremed in statistical analyses.
Rowing performance test will be conducted at the beginning and at the end of the training camp. Participants will perform a test on a rowing ergometer (Concept II, USA); each subject will have to cover a distance of 2000 m in the shortest possible time which is the distance starting in rowing competitions. The results of both tests will be considered in the selection for the championship team; therefore, athletes will be well motivated to perform both tests with maximum effort.
Hypotesis:
The krill oil will infleunce the gut barier integrity.
详细描述
All competitors will be randomly divided into two groups (double-blind):
A. supplemented (n = 15), who will receive one capsule of THYROX (Atlantic krill oil) four times a day.
B. control (n = 15) receiving placebo. The supplementation period will be six weeks.
Characteristic of the supplement:
THYROX (Atlantic krill oil). The daily recommended intake of krill oil is 2000 mg, which includes 350 mg of omega-3 fatty acids, 240 mg of EPA, 110 mg of DHA, 800 mg of phospholipids, and 200 mg of astaxanthin.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
Triple
入排标准
- 年龄范围
- 18 Years 至 24 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •training experience of a minimum of five years,
- •minimum training time per week 240 minutes,
- •all competitors qualified for the Polish Youth Rowing Team,
- •completing a food diary,
- •finishing 2000m ergometer test.
排除标准
- •Probiotics, prebiotics and antibiotic therapy within the last three months,
- •dietary regime,
- •gastrointestinal diseases,
- •lactose intolerance.
研究组 & 干预措施
Supplemented
(n = 15), who will receive one capsule of a supplement called THYROX (Atlantic krill oil) four times a day. The daily content of krill oil is 2000 mg, including omega-3 fatty acids 350 mg, EPA - 240 mg, DHA - 110 mg, phospholipids - 800 mg, astaxanthin 200 mg.
The supplementation period will be six weeks. Intervention: Drug: THYROX (Atlantic krill oil).
干预措施: THYROX (Atlantic krill oil (Dietary Supplement)
Control
receiving placebo Intervention: Drug: Placebo
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
I-FABP (intestinal fatty acid binding protein)
时间窗: Blood samples will be taken from the cubital vein at three-time points: before each stress test (after overnight fasting), one minute after the end of the test, and after a 3-hour recovery period.
gut injury (enterocyte)
LBP (lipopolysaccharide binding protein)
时间窗: Blood samples will be taken from the cubital vein at three-time points: before each stress test (after overnight fasting), one minute after the end of the test, and after a 3-hour recovery period.
endotoxin
CLDN-3
时间窗: Blood samples will be taken from the cubital vein at three-time points: before each stress test (after overnight fasting), one minute after the end of the test, and after a 3-hour recovery period.
gut injury (tight junction)
CD14
时间窗: Blood samples will be taken from the cubital vein at three-time points: before each stress test (after overnight fasting), one minute after the end of the test, and after a 3-hour recovery period.
endotoxin
Catechyloamines, cortisol
时间窗: Blood samples will be taken from the cubital vein at three-time points: before each stress test (after overnight fasting), one minute after the end of the test, and after a 3-hour recovery period.
stress hormones
次要结局
- Food intake(day before the test, morning before the test)