Modelling Internal Hepatic Movement With an External Abdominal Marker

• Conditions: Patients With Liver Metastases From Colorectal Cancer

• Registration Number: NCT00299299
• Lead Sponsor: Royal Marsden NHS Foundation Trust

Brief Summary

This study tests the feasibility and reproducibility of patient-specific motion models. These will be used for quantification of safe margin reduction. Patient-specific motion models will be built by post-processing 4D MRI data with non-rigid registration. By comparing these models between visits, model reproducibility will be assessed, and the methodology refined.

Detailed Description

The study will use a real time position management (RPM) system for respiratory gating. The RPM system senses the respiration motion of the patient by tracking a pair of reflective markers on a lightweight "marker block" constructed of a synthetic material. This block is placed on the patient's abdomen.

During Radiotherapy, the beam is only switched on at pre-determined phases of respiration. The appropriate phase of respiration is determined by the RPM system. This implies a reliable correlation of external block motion to internal hepatic movement. This correlation is not a simple one, and requires "modeling".

Study Timeline

• Study First Submitted: 2006-03-03
• Study First Submitted QC: 2006-03-03
• Study First Posted: 2006-03-06
• Study Start: 2006-06
• Status Verified: 2010-01
• Last Update Submitted: 2010-01-11
• Last Update Posted: 2010-01-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Histologically confirmed adenocarcinoma compatible with primary disease in the colon or rectum
• Aged 18 years or older
• Unequivocal contrast-enhanced CT and/or MRI evidence of malignant single or multiple metastases in the liver, metastases at other sites will not be an exclusion criterion
• WHO performance status 0-2 and life expectancy of at least 12 weeks
• Informed written consent

Exclusion Criteria

• Pregnancy or breast feeding
• Evidence of ascites
• Patients unable for whatever reason to lie flat
• Patients unable to give fully informed consent
• Age< 18 years

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Royal Marsden Hospital; 🇬🇧 Chelsea, United Kingdom