Add-on to Cognitive, ERP and EEG Asymmetry in Affective Disorders (#6559R) [Formerly #5723]
试验速览
- 阶段
- 4 期
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Hamilton Rating Scale
研究概览
简要总结
Depressed patients unremitted after monotherapy with citalopram or bupropion will remit following six weeks treatment with the combination of citalopram and bupropion.
详细描述
Participants in another study who did not remit during 12 weeks treatment with citalopram (to 40 mg/d) or bupropion (to 450 mg/d) will have citalopram (to 40 mg/d) or bupropion (to 450 mg/d) added for six weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 66 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •non-remission in Protocol #6559R
- •age 18-66
- •signs informed consent
- •physically healthy
排除标准
- •bipolar disorder
- •history of psychosis
- •history of anorexia nervosa or bulimia
- •history of seizure disorder, significant brain trauma or other medical reason to suspect increased seizure risk
研究组 & 干预措施
citalopram added to bupropion
Patients who did not remit with bupropion will have bupropion continued at the same dose and citalopram will be added
干预措施: citalopram (Drug)
bupropion added to citalopram
patients who did not remit with citalopram will continue at the same dose and have bupropion added
干预措施: bupropion (Drug)
bupropion added to citalopram
patients who did not remit with citalopram will continue at the same dose and have bupropion added
干预措施: citalopram (Drug)
citalopram added to bupropion
Patients who did not remit with bupropion will have bupropion continued at the same dose and citalopram will be added
干预措施: bupropion (Drug)
结局指标
主要结局
Hamilton Rating Scale
时间窗: weeks 6
Decrease in score for Hamilton Rating Scale for Depression, 17-item version
次要结局
未报告次要终点