A comparative study in sauna-induced dehydration model of healthy adults to investigate the effect of HS-12S and commercial mineral water on benefit of water-electrolyte supplementation.
- Conditions
- Dehydrated
- Registration Number
- JPRN-UMIN000021059
- Lead Sponsor
- Takeda Pharmaceutical Company Limited
- Brief Summary
The rates of weight gain during the sauna bath and 4 hours after intake of fluids were compared for HS-12S and MW groups. It was observed that the absolute rate in the HS-12S group was significantly lower than that in MW group. Further, compared with the MW group, the HS-12S group showed significant recovery in terms of changes in serum osmolality; serum levels of total protein, total albumin, Na , and Cl; and urenary levels of Cl. Compared to MW, HS-12S was more effective in water-electrolyte supplementation in a sauna-induced dehydration model. We conclude that a hypotonic drink such as HS-12S, which contains sodium and glucose, is beneficial during mild dehydration because of its water-electrolyte supplementation efficacy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Male
- Target Recruitment
- 24
Not provided
1) Person with serious cardio-vascular, hepatic, renal, respiratory, endocrine or metabolic diseases, or who has a medical history of these disorders 2) Person who donated more than 200 mL of blood in the last one month, who donated more than 400 mL of blood in the last three months, and/or who donated blood components in the last two weeks 3) Person was included in other clinical studies in the last four months or who is now included in other clinical studies 4) Person considered not suitable for the study by the investigators
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method body weight after 1,2,3,4 hour(s) intervention
- Secondary Outcome Measures
Name Time Method Blood tests; hematocrit, hemoglobin, Na, K, Cl, total protein, albumin, blood urea nitrogen, creatinine, glucose, serum osmolality Urine tests; urine volume, urine osmolality, Na, K, Cl, creatinine fractional excretion of sodium, water-electrolyte balance (Na, K, Cl)