The effect of moderate alcohol consumption on subsequent food reward

Completed

• Conditions: Obesity; 10018424; 10003018

• Registration Number: NL-OMON36969
• Lead Sponsor: TNO

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

1. Caucasian men, this means that at least both parents and the subject himself should be of the Caucasian race;
2. Age 25-50 years (inclusive) on the day of the screening;
3. Body Mass Index (BMI) of 20-25 kg/m2 (inclusive);
4. Body weight of 60-100 kg (inclusive);
5. Able to read, write and fully understand the Dutch language, and
6. Able to participate in the study, willing to give written informed consent and to comply with the study procedures and restrictions

Exclusion Criteria

1. Above average score (>2.26) on the restrained eating scale of the Dutch Eating Behaviour Questionnaire;
2. Alcohol consumption <=5 and >= 21 standard glasses/week;
3. Not having regular and normal Dutch eating habits (consuming mostly 3 main meals including breakfast);
4. Not having a normal day/night rhythm;
5. Smoking, or stopped with smoking <3 months prior to start of the study;
6. Using drugs, or stopped using drugs <3 months prior to start of the study;
7. Having a (family) history of alcohol or drug related problems;
8. Reported slimming or being on a medically described diet;
9. Having a vegan, vegetarian or macrobiotic lifestyle;
10. Loss of blood outside the limits of Sanquin within 3 months prior to screening;
11. Participation in a clinical trial within 3 months prior to the start of this study or more than 4 times a year;
12. Having a food allergy, sensitivity or disliking of one of the foods used in the study;
13. Reported unexplained weight loss or gain of >4 kg in the month prior to screening;
14. Inappropriate veins for cannula insertion;
15. Not having a general practitioner or health insurance;
16. Having a history of medical or surgical events or disease that may significantly affect the study outcome, particularly physiological disorders, metabolic or endocrine disease and gastrointestinal disorders; and/or
17. Any conditions which, in the opinion of the investigator, might create undue risk to the subject or interfere with the subject's ability to comply with the protocol.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Questionnaire measuring food wanting explicitly (VASfood)<br /><br>- Questionnaire measuring food wanting explicitly for different food categories<br /><br>(LFPQ)<br /><br>- Computer task measuring food wanting implicitly for different food categories<br /><br>(LFPQ)<br /><br>- Questionnaire measuring food liking explicitly for different food categories<br /><br>(LFPQ)<br /><br>- Questionnaire measuring hunger, fullness and prospective<br /><br>food consumption (VASfood)<br /><br>- Ad libitum food intake<br /><br>- Breath alcohol concentration</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Computer task measuring food preferences (LFPQ)<br /><br>- GLP-1 in plasma<br /><br>- Ghrelin in plasma<br /><br>- N-acyl ethanolamides in plasma<br /><br>- Leptin, Insulin, FFA and glucose in serum<br /><br>- Ghrelin in saliva<br /><br>- N-acyl ethanolamides in saliva</p><br>