Effects of Wound Infiltration With Ketamine Versus Dexmedetomidine Added to Bupivacaine on Cytokines

Phase 4

Completed

• Conditions: Endometrial Adenocarcinoma
• Interventions: Drug: Ketamine; Drug: dexmedetomidine; Drug: bupivacaine

• Registration Number: NCT03164590
• Lead Sponsor: Assiut University

Brief Summary

This study aims to compare the effects of local wound infiltration with ketamine versus dexmedetomidine when added to bupivacaine on inflammatory cytokine response after total abdominal hysterectomy.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2017-05-22
• Study First Submitted QC: 2017-05-22
• Study First Posted: 2017-05-23
• Study Start: 2017-06-01
• Status Verified: 2018-01
• Primary Completion: 2018-08-01
• Study Completion: 2018-09-01
• Last Update Submitted: 2020-01-19
• Last Update Posted: 2020-01-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

• ASA I-II patients
• age range (18-60) years,
• weight (50- 90) kg

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Exclusion Criteria

• allergy to study drugs
• significant cardiac disease
• respiratory disease
• renal disease
• hepatic disease

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
ketamine	Ketamine	-
bupivacaine	Ketamine	-
bupivacaine	bupivacaine	-
dexmedetomidine	dexmedetomidine	-
bupivacaine	dexmedetomidine	-

Primary Outcome Measures

Name	Time	Method
severity of pain at rest and on coughing	24 hours	severity of pain at rest and on coughing will be assessed using a 10-cm Visual Analog Scale (0 = no pain and 10 = worst imaginable pain)

Secondary Outcome Measures

Name	Time	Method
sedation	24 hours	sedation by using sedation score

Trial Locations

Locations (1)

South Egypt Cancer instIitute; 🇪🇬 Assuit, Egypt