Assessment of Stroke Volume in Shock Using Echocardiography Versus Bioreactive Impedance

Recruiting

• Conditions: Shock; Critical Illness

• Registration Number: NCT07020637
• Lead Sponsor: University of Nevada, Las Vegas

Brief Summary

This study aims to evaluate the correlation between stroke volume measurements obtained by transthoracic echocardiography and bioreactance-based noninvasive cardiac output monitoring. The primary objective is to assess the level of agreement between these two modalities in critically ill patients.

Detailed Description

In this prospective observational study, patients presenting with clinical signs of shock will be enrolled after obtaining informed consent. Stroke volume (SV) will be measured using both transthoracic echocardiography and bioreactance-based noninvasive cardiac output monitoring (Cheetah NICOM). SV will be recorded before and after passive leg raising (PLR) to evaluate the correlation between the two methods in terms of absolute values and directional changes (increase or decrease). No therapeutic intervention will be performed as part of the study; all clinical decisions will remain under the discretion of the treating medical team.

Study Timeline

• Study Start: 2024-10-19
• Status Verified: 2024-12
• Study First Submitted: 2025-06-05
• Study First Submitted QC: 2025-06-05
• Study First Posted: 2025-06-13
• Last Update Submitted: 2025-06-13
• Last Update Posted: 2025-06-18
• Primary Completion: 2026-07-01
• Study Completion: 2026-09-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Not provided

Exclusion Criteria

• Pregnancy
• Known severe aortic valve disease or dynamic left ventricular outflow tract obstruction
• Morbid obesity (BMI > 40) that precludes accurate echocardiographic imaging Presence of cardiac arrhythmias (e.g., atrial fibrillation with rapid ventricular response) affecting stroke volume measurements
• Implanted cardiac assist devices (e.g., LVAD, pacemaker dependency)
• Imminent death or decision for comfort care only

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation Between Stroke Volume Measurements by Echocardiography and Bioreactance Monitoring	Within 1 hour of enrollment	Pearson correlation coefficient between stroke volume measurements obtained using transthoracic echocardiography and those obtained using bioreactance-based monitoring (Cheetah NICOM) in response to passive leg raising.

Trial Locations

Locations (1)

University Medical Center Southern Nevada; 🇺🇸 Las Vegas, Nevada, United States