Comparison of Time to Orientation between Combining Propofol with Sevoflurane and Sevoflurane in Patients undergoing Endoscopic Transnasal Surgery

Phase 4

Recruiting

• Conditions: pituitary tumorsinusitis; propofol; sevoflurane; coadministration; transsphenoidal surgery; postoperative nausea and vomiting (PONV); endoscopic sinus surgery; functional endoscopic sinus surgery (FESS)

• Registration Number: TCTR20210924006
• Lead Sponsor: Khon Kaen University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-09-24
• Study Completion: 2022-06-08
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 38

Inclusion Criteria

1.Age 18-60 years old
2.ASA physical status I-III
3.BMI 18-35 kg/m2

Exclusion Criteria

1.Emergency surgery/unstable hemodynamics
2.Pregnancy
3.End stage renal disease or cirrhosis
4.Cognitive impairment
5.History of uncontrolled hypertension
6.Heart block greater than first degree
7.Obstructive sleep apnea
8.Chronic use of pain control
9.Allergy to the drugs used in the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time to orientation emergence of anesthesia timer, clock

Secondary Outcome Measures

Name	Time	Method
Time from reversal to spontaneous ventilation, eye opening responded to sound and extubation emergence of anesthesia timer, clock,Incidence of serious coughing emergence of anesthesia observation,agitation emergence of anesthesia Ricker sedation-agitation scale,Pain score postanesthetic care unit numerical rating scale (NRS) ,Hemodynamics base line, intraoperative Mean arterial pressure, heart rate,Incidence of nausea and vomiting postanesthetic care unit 0 none, 1 mild, 2 severe nausea requiring antiemetics, 3 retching, vomiting or both