Fatigue in autosomal dominant spinocerebellar ataxia (ADCA) and idiopatic late onset cerebellar ataxia (ILOCA)

Recruiting

Conditions: ataxia
spinocerebellar ataxia
10028037

Registration Number: NL-OMON32846

Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 94

Inclusion Criteria

diagnosis of autosomal dominant spinocerebellar ataxia (ADCA) or idiopatic late onset cerebellar ataxia (ILOCA), age of 18 years and beyond, able to interpretate self-assessment scales, signed informed consent

Exclusion Criteria

ataxia of unknown origin or other diagnosis
age below 18 years
severe psychiatric or cognitive deterioration or other conditions that prevent patients from adequate interpretation of self assessment scales

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary study parameters are: difference in FSS-score in our study population<br /><br>compared to (published) FSS scores in healthy controls and furthermore the<br /><br>correlation of FSS score and disease duration, severity of ataxia (quantified<br /><br>with the SARA: scale for assessment and rating of ataxia) and depression<br /><br>(quantified in the Beck depression inventory). , </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters are: independent correlates of fatigue, studying the<br /><br>association of frequency and severity of fatigue, measured by FSS, and quality<br /><br>of life, motor function, disorders of sleep and cognitive functioning, assessed<br /><br>by the SF-36, the Rotterdam handicap scale, the Pittsburg sleep quality index,<br /><br>the Epworth sleepiness scale(ESS) and the mini mental state examination (MMSE) </p><br>