The blood concentration of acetaminophenin and analgesic effect

Phase 1

• Conditions: Post operative pain; acetaminophen, predicted cerebrospinal fluid concentration, pain threshold

• Registration Number: JPRN-jRCTs031200321
• Lead Sponsor: Akiko Nishimura

Brief Summary

The analgesic effect of acetaminophen was shown to occur significantly at 2 hours after administration, indicating a discrepancy between the blood concentration of acetaminophen and the analgesic effect. We simulated PK/PD model estimated from the blood concentration and the rate of change of PEC for each subject.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-01-21
• Study Completion: 2021-03-09
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

Volunteers who understand about this study and give informed consent with free will

Exclusion Criteria

1) Patients who use cardiac pacemaker device
2) Expectant or nursing mothers
3) Patients who have severe hepatic impairment
4) Patients who have allergy to acetaminophen
5) Patients who have peptic ulcer
6) Patients who have hematological disorder
7) Patients who have severe kidney impairment
8) Patients who have severe cardiac dysfunction
9) Patients who have aspirin asthma
10)Patients who is judged ineligible by the doctor in charge

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
minimum perceived current,pain response current, blood concentration of acetaminophen

Secondary Outcome Measures

Name	Time	Method
predicted cerebrospinal fluid concentration of acetaminophen, adverse effects