Comparative study oneffect of Nitroglycerin and Misoprostol oncervical ripeningbefore curettage in wome

Phase 3

Recruiting

Conditions: Pregnancy ,Medical abortion, Nitroglycerin ., Misoprostol ,cervical ripening.
XV Pregnancy, childbirth and the puerperium ,Medical abortion
XV004

Registration Number: IRCT20210510051247N1

Lead Sponsor: Rasht University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Female

Target Recruitment: 170

Inclusion Criteria

After obtaining full consent to participate in the study, pregnant women are candidates for curettage with a gestational age of less than 14 weeks who have a reason for termination of pregnancy (missed abortion, medical abortion) based on the case file documents And have normal vital signs including no fever( less than 38 ° C), normal heart rate between 70 and 100 and systolic blood pressure between 100 and 130. Also have a history of uterine scarring at most once, no drug abuse, no bleeding (based on initial examination )Lack of coagulation disorder or recent history of anticoagulants, no active liver disease, cardiovascular disease, uncontrolled seizures, history of glaucoma, adrenal insufficiency are the conditions for inclusion in the study.

Exclusion Criteria

Patients who wish to have a medical abortion and are not candidates for curettage surgery for any reason. Women who have more than one history of uterine scarring are not included in the study

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cervical ripening. Timepoint: Initial examination and 4 hours after receiving the drug. Method of measurement: Hegar Bogey No. 8 passes through the cervix.

Secondary Outcome Measures

Name	Time	Method
Requires mechanical dilatation. Timepoint: During curettage. Method of measurement: HegarBogey No. 8 passes through the cervix.;Possible side effects (diarrhea, chills, abdominal pain, headache, hypotension and palpitations). Timepoint: Every 4 hours during hospitalization. Method of measurement: Questioning the patient, examination, control of vital signs.