Effects of pressure versus volume controlled mechanical ventilation on intracranial pressure and cerebral perfusion pressure – A pilot study

Not Applicable

Conditions: I60.1
S06
I63.1
I61.0
Subarachnoid haemorrhage from middle cerebral artery
Intracranial injury
Cerebral infarction due to embolism of precerebral arteries
Intracerebral haemorrhage in hemisphere, subcortical

Registration Number: DRKS00009832

Lead Sponsor: Klinikum Kassel, Neurologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 30

Inclusion Criteria

need for mechanical ventilation
- need for ICP monitoring
- written informed consent by legal proxy

Exclusion Criteria

- assisted breathing, spontanious breathing
- severe respiratory failure (FiO2 <= 45%,P/F ratio < 200, PEEP > 10mmHg)
- elevated ICP > 25mmHg and need for ICP therapy within the last 6 hours
- Circulatory shock: shock index >1 (Heart frequency/ systolic blood pressure) within the last 6 hours
- fever: body temperature >= 38,5°C within the last 6 hours
- acidosis: PH < 7,35 within the last 6 hours
- blood glucose level < 60mg//dl or > 500mg/dl within the last 6 hours
- severe respiratory diseases such as lung fibrosis or COPD
- prone positioning

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
fluctations of ICP (intracranial pressure) values during pressure-controlled mode ventilation compared to volume-controlled mode ventilation. ICP is measured continuously via intraparenchymatous ICP monitoring. This study had no influence on the indication of ICP monitoring.

Secondary Outcome Measures

Name	Time	Method
- mean ICP and CPP (cerebral perfusion pressure) values<br>- frequency of ICP increases above critical values of 20 mmHg or more <br>- frequency of CPP decreases of 50 mmH or lower <br>- need for ICP therapy <br>- frequency of respiratory complications. <br>