Reason Evaluation of Initial Treatment Failure in Patients With CAP

• Conditions: Community-acquired Pneumonia
• Interventions: Drug: Moxifloxacin Hydrochloride and Sodium Chloride Injection

• Registration Number: NCT03280004
• Lead Sponsor: Peking Union Medical College Hospital

Brief Summary

This research is to evaluate the effect of different antibiotics (Moxifloxacin Hydrochloride and Sodium Chloride Injection vs. β-lactam antibiotics for injection +/- Azithromycin for Injection) on the early deterioration or progression (\<72 h of treatment) of community acquired pneumonia and to study the effect of the early deterioration or progression on the prognosis of community acquired pneumonia.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-09-10
• Study First Submitted QC: 2017-09-10
• Study First Posted: 2017-09-12
• Study Start: 2017-11-20
• Status Verified: 2019-04
• Last Update Submitted: 2019-04-26
• Last Update Posted: 2019-04-29
• Primary Completion: 2019-08-31
• Study Completion: 2019-11-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 314

Inclusion Criteria

1. Age>=18y.
2. Diagnosed with CAP.
3. Need hospitalization.
4. Receive Moxifloxacin Hydrochloride and Sodium Chloride Injection or β-lactam antibiotics for injection +/- Azithromycin for Injection as initial treatment.
5. Signed informed consent form.

Exclusion Criteria

Patients who meet any of the following criteria will not be included in the study:

1. Pneumonia is aquired more than 48h after admission or the patient was admitted to hospital within 30 days prior to admission.
2. Start antibiotic treatment before admission.
3. Gestational period or suckling period.
4. Admitted to ICU.
5. Immunocompromised patients.
6. Pneumonia is the terminal event of a serious disease.
7. Tuberculosis, lung cancer, non-infectious interstitial lung disease, pulmonary edema, atelectasis, pulmonary embolism, pulmanory eosinophilia, pulmonary vasculitis.
8. Allergic to the antibiotics of the study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Moxifloxacin group	Moxifloxacin Hydrochloride and Sodium Chloride Injection	-

Primary Outcome Measures

Name	Time	Method
early deterioration or progression rate	3 days

Trial Locations

Locations (1)

Jun Xu; 🇨🇳 Beijing, Beijing, China