Efficacy of nalbuphine as an adjuvant to levobupivacaine scalp nerve block on intraoperative hemodynamic response and postoperative analgesia in elective supratentorial craniotomy
Phase 4
Completed
- Conditions
- Scalp nerve block, Supratentorial craniotomy, Hemodynamic response, Postoperative analgesia, Levobupivacaine, Nalbuphine
- Registration Number
- TCTR20221124002
- Lead Sponsor
- Department of anesthesiology, King chulalongkorn Memorial hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Age 20 to 65 year-olds
ASA Physical Status I and II
Undergoing elective supratentorial craniotomy for the first time
Exclusion Criteria
Allergic to levobupivacaine, nalbuphine
Infection at the block site/ Scalp Infection
Preoperative Glasgow Coma Scale (GCS) < 15
Inability to measure pain intensity by verbal numeric rating scale (NRS)
Inability to use PCA
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Duration of postoperative analgesia between groups 24 hour post operative Time to first rescue fentanyl
- Secondary Outcome Measures
Name Time Method Perioperative hemodynamic responses intraoperative and post operative first 24 hour Mean arterial pressure(MAP), Heart rate(HR),Overall pain score over the first 24 postoperative hour post operative first 24 hour Numaric rating scale(NRS),Incidence of side effects post operative first 24 hour PONV score, glasgow coma score(GCS)