Buprenorphine (CAM2038) in Subjects With a Recent History of Moderate to Severe Chronic Low Back Pain

Phase 3

Completed

Conditions: Chronic Lower Back Pain
Chronic Pain

Interventions: Other: Placebo
Drug: buprenorphine

Registration Number: NCT02946073

Lead Sponsor: Braeburn Pharmaceuticals

Brief Summary: This is a Phase III, placebo-controlled, multicenter study with an enriched-enrollment withdrawal (EEW) design to evaluate the efficacy and safety of CAM2038 in opioid-experienced subjects with moderate to severe CLBP that requires continuous, around-the-clock (ATC) opioid treatment ≥ 40 mg morphine equivalent dose (MED). The study includes 5 phases: A Screening Phase (up to 2 weeks), a Transition Phase (up to 2 weeks), an Open-Label Titration Phase (up to 10 weeks), a Double-Blind Treatment Phase including a Final Study Visit (12 weeks), and a Follow-up Phase (4 weeks). The overall duration of participation in the core phase of the study (randomized Double-Blind Phase) is up to 30 weeks, from the Screening Phase through the Follow-up Phase. Subjects who complete the Double-Blind Treatment Study Phase will be offered an opportunity to continue treatment in an open label safety extension for up to 60 weeks. Additional subjects may be recruited to open label safety extension to meet the goal of 100 subjects with 60 weeks of treatment.

Detailed Description: Not available

Recruitment & Eligibility

Status: COMPLETED

Sex: All

Target Recruitment: 1053

Inclusion Criteria

Written informed consent provided prior to the conduct of any study-related procedures.
Male or non-pregnant, non-lactating female subject, greater than or equal to 18 years old.
Body mass index (BMI) between 18 and 38 kg/m2, inclusive.
Treated with daily opioids for moderate to severe CLBP for a minimum of 3 months prior to Screening.
On a stable dose of ≥40 mg/day of oral morphine or MED during the 14 days prior to Screening.
Systolic blood pressure ≥100 mmHg and diastolic blood pressure ≥60 mmHg.
Female subject of childbearing potential who is willing to use a reliable method of contraception during the entire study (Screening Visit to final Follow-up). To be considered not of childbearing potential, female subjects must be surgically sterile (hysterectomy or bilateral oophorectomy, or bilateral tubal ligation with surgery at least 6 weeks before Screening).
Male subject who is willing to use reliable contraception
Willing and able to comply with all study procedures and requirements.

Exclusion Criteria

Positive for hepatitis B surface antigen, hepatitis C viral RNA, or antibodies to human immunodeficiency virus (HIV).
Clinically significant symptoms, medical conditions, or other circumstances which, in the opinion of the investigator, would preclude compliance with the protocol, adequate cooperation in the study, or obtaining informed consent, or may prevent the subject from safely participating in the study, including the following:
1. Severe respiratory insufficiency, respiratory depression, airway obstruction, gastrointestinal motility disorders, biliary tract disease, severe hepatic insufficiency, or planned surgery.
2. Bipolar disorder
Current diagnosis of Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition-defined moderate to severe substance use disorder (including alcohol), other than caffeine or nicotine.
Female subject planning to become pregnant during the study.
Surgical procedure(s) for CLBP within 6 months prior to Screening.
Concomitant disease(s) that could prolong the QTcF interval, such as autonomic neuropathy (caused by diabetes or Parkinson's disease), HIV, cirrhosis, Long QT Syndrome, or family history of Long QT Syndrome.
QTcF >450 ms for males and >470 ms for females, or clinically significant electrocardiogram (ECG) abnormality at Screening, at the investigator's discretion.
Currently taking medications that have the potential to prolong the QTcF interval or may require such medications during the course of the study (Appendix 1) and has clinically significant abnormalities on screening ECG readings, as determined by the investigator.
A nerve or plexus block, including epidural steroid injections or facet blocks, within 1 month prior to Screening or botulinum toxin injection in the lower back region within 3 months of Screening.
History of chemotherapy or confirmed malignancy (except basal cell carcinoma) within the past 2 years.
Any other acute or chronic pain condition that could interfere with the subject's ability to report their CLBP accurately and consistently and/or interfere with the study staff's ability to assess the subjects CLBP.
An active or pending workman's compensation, insurance claim, or litigation related to back pain (i.e., primary claim is back pain).
Clinically significant history, in the opinion of the investigator, of suicidal ideation or current evidence that the subject is actively suicidal.
Clinically significant history of major depressive disorder that is poorly controlled with medication, per investigator judgment.
Hypersensitivity or allergy to BPN, other opioids, or excipients of CAM2038.
Hypersensitivity or allergy to acetaminophen.
Use of strong inhibitors or inducers of cytochrome P450 3A4 (CYP3A4), such as some azole antifungals (e.g., ketoconazole), macrolide antibiotics (e.g., clarithromycin), or protease inhibitors (e.g., ritonavir, indinavir, and saquinavir) within the 30 days prior to Screening,
Use or planned use of natural supplements that can affect CYP3A4, such as St. John's Wort, throughout the study.
Has a major bleeding disorder, such as hemophilia, or treated with high levels of anticoagulants per the investigator's discretion.
Current or confirmed past diagnosis of Sphincter of Oddi dysfunction.
Has a significant hepatic disease, as indicated by Screening clinical laboratory assessment results (aspartate aminotransferase, alanine aminotransferase, or lactate dehydrogenase values ≥3 × the upper limit of normal [ULN]) or has a creatinine value ≥1.5 × ULN).
Is an employee of the investigator or the trial site, with direct involvement in the proposed trial or other studies under the direction of the investigator or trial site or is a family member of the investigator or of an employee of the investigator.
Has any pending legal action that could prohibit participation or compliance in the study.

Criteria for Entry into the Titration Phase:

After at least a 12-hour washout from the last IR morphine dose, subject must have a COWS ≥5 and an API pain score over the past 24 hours ≥5 in order to receive a test dose of Buprenex.
Passed all baseline criteria, including a normal QTcF, had no change in QTcF >30 ms at 1 hour after the test dose with Buprenex, and had a COWS score <5 after the test dose with Buprenex.

Note:

Subjects on BPN at Screening are required to participate in the down titration and will undergo a washout period prior to the test dose and first on-study treatment. Subjects entering the study on BPN will not transition to IR Morphine, but will refrain from taking their BPN for 12 -24 hours prior to the test dose to achieve the desired washout period.
Subjects on BPN at Screening are still required to follow the same Day 1 procedures (e.g., confirmation of pain scores, COWS assessment and Buprenex test dose) as non-BPN subjects.

Criteria for Randomization into the Double-Blind Phase:

Been on a stable dose of CAM2038 q1w for at least 2 consecutive weeks.
CAM2038 titrated to a dose that provides analgesia (i.e., 7-day API score of ≤4 and at least 2 points below the value at the start of Titration Phase) and is well tolerated for 7 days before randomization.
Requires no more than an average of one hydrocodone/acetaminophen 5 mg/325 mg/day during the last 7 days prior to randomization.
Demonstrated study medication (CAM2038) compliance ≥80% during the previous 14 days.
Demonstrated daily compliance with pain intensity scoring for ≥11 of the previous 14 days, including the last 3 days prior to randomization.

Inclusion Criteria for Open Label Extension For Subjects Continuing from The Randomized Double-Blind Phase.

Subjects must have:

Completed Double Blind Phase of the study
Signed Informed Consent for Safety Extension

Subjects completing the double-blind phase will be enrolled directly into the open label extension at their respective dose level of CAM2038. They will not be required to participate in a Buprenex treatment test dosing or participate in a titration phase.

For De Novo Subjects (New Subjects Recruited Directly into The Open Label Extension)

Subjects who are not participating in the Double-Blind Phase of the Study must meet all of the following inclusion criteria in order to be eligible for participation in the study:

Written informed consent provided prior to the conduct of any study-related procedures.
Male or non-pregnant and non-lactating female subject, greater than or equal to 18 years old.
BMI between 18 and 38 kg/m2, inclusive.
Treated with daily opioids for moderate to severe chronic pain disorder such as CLBP or osteoarthritis for a minimum of 3 months prior to Screening.
On a stable dose of >40 mg/day of oral morphine or MED during the 14 days prior to Screening.
Systolic blood pressure ≥100 mmHg and diastolic blood pressure ≥60 mmHg.
Female subject of childbearing potential who is willing to use a reliable method of contraception during the entire study (Screening Visit to final Follow-up). To be considered not of childbearing potential, female subjects must be surgically sterile (hysterectomy or bilateral oophorectomy, or bilateral tubal ligation with surgery at least 6 weeks before Screening).
Male subject who is willing to use reliable contraception
Willing and able to comply with all study procedures and requirements.

Exclusion Criteria for Subjects Continuing from The Randomized Double-Blind Phase

Clinically significant symptoms, medical conditions, or other circumstances which, in the opinion of the investigator, would preclude compliance with the protocol, adequate cooperation in the study, or obtaining informed consent, or may prevent the subject from safely participating in the study.

Exclusion Criteria for De Novo Subjects only:

Same exclusion criteria as for subjects participating in the Randomized Double-Blind Treatment Phase.

Criteria for Entry into the Titration Phase (for De novo subjects):

After at least a 12-hour washout from the last IR morphine dose, subject should have a COWS ≥5 and an API pain score over the past 24 hours ≥5 in order to receive a test dose of Buprenex.
Passed all baseline criteria, including a normal QTcF, had no change in QTcF >30 ms at 1 hour after the test dose with Buprenex, and had a COWS score <5 after the test dose with Buprenex.

Note:

Subjects on BPN at Screening are required to participate in the down titration and will undergo a washout period prior to the test dose and first on-study treatment. Subjects entering the study on BPN will not transition to IR Morphine, but will refrain from taking their BPN for 12 -24 hours prior to the test dose to achieve the desired washout period.
However, subjects on BPN at Screening are still required to follow the same Day 1 procedures (e.g., confirmation of pain scores, COWS assessment and Buprenex test dose) as non-BPN subjects.

Criteria for Enrolment into the Open Label Treatment Phase (for de Novo subjects):

Been on a stable dose of CAM2038 q1w for at least 2 consecutive weeks.
CAM2038 titrated to a dose that provides analgesia (i.e., 7-day API score of ≤4 and at least 2 points below the value at the start of Titration Phase) and is well tolerated for 7 days before randomization.
Requires no more than an average of one hydrocodone/acetaminophen 5 mg/325 mg/day during the last 7 days prior to randomization

Study & Design

Study Type: INTERVENTIONAL

Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo	Placebo	CAM2038 placebo injections
CAM2038	buprenorphine	CAM2038 50 mg/mL q1w at doses of 8 mg, 12 mg, 16 mg, 24 mg, or 32 mg. CAM2038 356 mg/mL q4w at doses of 64 mg, 96 mg, or 128 mg.

Primary Outcome Measures

Name	Time	Method
Change From Baseline in Weekly Average of (Daily) Average Pain Intensity (WAAPI) and the Primary Timepoint Will be Week 12 of the Double-Blind Phase.	12 weeks- from randomization baseline to 12 weeks after randomization	Change from baseline in Weekly Average of (Daily) Average Pain Intensity (WAAPI) and the primary timepoint will be Week 12 of the Double-Blind Phase based on the 11-Point numerical rating scale with 0 being no pain and 10 being the worst pain.
Change From Baseline in Weekly Average of (Daily) Average Pain Intensity (WAAPI) of the Open Label Phase.	48 weeks -From baseline to 48 weeks after baseline (Baseline is defined as the last week prior to Visit 14 (Randomization Visit) for the roll-over subjects and the last week prior to Visit 14 (Enrollment Visit) for de novo subjects).	Change from baseline in Weekly Average of (Daily) Average Pain Intensity (WAAPI) of the Open Label Phase based on the 11-Point numerical rating scale with 10 being the worst pain. Baseline is defined as the last week prior to Visit 14 (Randomization Visit) for the roll-over subjects and the last week prior to Visit 14 (Enrollment Visit) for de novo subjects.

Secondary Outcome Measures

Name	Time	Method
Change From Baseline in the Weekly Average of (Daily) Worst Pain Intensity Scores at Week 12 of the Double-Blind Phase Based on 11-Point Numerical Rating Scale With 10 Being the Worst Pain.	12 weeks- from randomization baseline to 12 weeks after randomization	Change from baseline in Weekly Average of (Daily) Worst Pain Intensity (WAWPI) and the primary timepoint will be Week 12 of the Double-Blind Phase based on the 11-Point numerical rating scale with 0 being no pain and 10 being the worst pain.
Change From Baseline in Weekly Average of (Daily) Worst Pain Intensity (WAWPI) of the Open Label Phase.	48 weeks -From baseline to 48 weeks after baseline (Baseline is defined as the last week prior to Visit 14 (Randomization Visit) for the roll-over subjects and the last week prior to Visit 14 (Enrollment Visit) for de novo subjects).	Change from baseline in Weekly Average of (Daily) Worst Pain Intensity (WAWPI) and the primary timepoint will be Week 52 of the Open Label Phase based on the 11-Point numerical rating scale with 10 being the worst pain. Baseline is defined as the last week prior to Visit 14 (Randomization Visit) for the roll-over subjects and the last week prior to Visit 14 (Enrollment Visit) for de novo subjects.
Subject Discontinued Due to Loss of Efficacy, Defined as Discontinuation of Study Drug for Lack of Efficacy.	48 weeks -From baseline to 48 weeks after baseline (Baseline is defined as the last week prior to Visit 14 (Randomization Visit) for the roll-over subjects and the last week prior to Visit 14 (Enrollment Visit) for de novo subjects).	Subject Discontinued Due to Loss of Efficacy, Defined as Discontinuation of Study Drug for Lack of Efficacy Open Label Phase.
Summary of Change From Baseline in Patient Global Impression of Improvement (PGI-I) Scale	48 weeks -From baseline to 48 weeks after baseline (Baseline is defined as the last week prior to Visit 14 (Randomization Visit) for the roll-over subjects and the last week prior to Visit 14 (Enrollment Visit) for de novo subjects).	Change from baseline in the Open Label Phase in Patient global Impression of Improvement (PGI-I) Scale. PGI-I Scale is a single question 7-point likert scale that required the subject to assess how much his/her pain had improved or worsened relative to the start of the study. Ratings were: 1, much worse; 2, worse; 3, a little worse; 4, no change; 5, a little better; 6, better; or 7, much better
Number of Subjects Discontinued Due to Loss of Efficacy	48 weeks -From baseline to 48 weeks after baseline (Baseline is defined as the last week prior to Visit 14 (Randomization Visit) for the roll-over subjects and the last week prior to Visit 14 (Enrollment Visit) for de novo subjects).	Number of Subjects Discontinued due to loss of efficacy, defined as discontinuation of study drug for lack of efficacy.
Change From Baseline to Week 12 of the Double-Blind Phase in Patient Global Impression of Improvement (PGI-I) Scale	12 weeks- from baseline (randomization) to 12 weeks after randomization	Change from baseline to Week 12 of the Double-Blind Phase in Patient global Impression of Improvement (PGI-I) Scale. PGI-I)Scale is a single question 7-point likert scale that required the subject to assess how much his/her pain had improved or worsened relative to the start of the study at the beginning of the intervention . Ratings were: 1, much worse; 2, worse; 3, a little worse; 4, no change; 5, a little better; 6, better; or 7, much better
Number of Subjects With a 30% and 50% Reduction in WAAPI From Baseline to Week 12 of the Double-Blind Phase.	12 weeks- from randomization baseline to 12 weeks after randomization	Number of Responders With a 30% and 50% Reduction in WAAPI from the Open-Label Titration Period Baseline to Week 12 of the Double-Blind Treatment Period (mITT Population)
Summary of Rescue Medication Usage- Double-Blind Phase.	12 weeks- from randomization baseline to 12 weeks after randomization	Rescue medication usage (number of days used) during the Double-Blind Phase.
Change From Open Label Titration Baseline to Week 12 of the Double-Blind Phase in EuroQol Group 5-dimension 5-level Self-report Questionnaire Score.	12 weeks- from randomization baseline to 12 weeks after randomization	Change from Open Label Titration baseline to Week 12 of the Double-Blind Phase in EuroQol Group 5-dimension 5-level self-report questionnaire score. The EuroQoL Group 5-Dimension 5-Level Self-Report Questionnaire (EQ-5D-5L) descriptive system is a generic, multidimensional, health-related, quality-of-life instrument. The profile allows subjects to rate their health state in 5 health domains: mobility, self-care, usual activities, pain/discomfort, and mood, using a 5-level scale. These combinations of attributes were converted into a weighted health-state index score, according to the US population-based algorithm, with higher scores indicating better quality of life. The score ranges from 0-100 with 0 as the worst health and 100 as the best health.
Change From Baseline to Week 12 of the Double-Blind Phase in Work Productivity and Activity Impairment Score	23 weeks- from baseline to 12 weeks after randomization	Change from baseline to Week 12 of the Double-Blind Phase in Work Productivity and Activity Impairment score. The Work Productivity and Activity Impairment (WPAI) is a self-administered instrument used to measure the effect of general health and symptom severity on work productivity and regular activities, and yields 4 types of scores (higher scores indicate greater impairment): Absenteeism (work time missed)，Presenteeism (impairment at work/reduced on-the-job effectiveness), Work Productivity Loss (overall work impairment/absenteeism plus presenteeism)，and Activity Impairment. Scores range from 0-100 for each of the four types with higher scores indicating greater impairment.
Summary of Rescue Medication Usage-Open Label Phase	48 weeks -From baseline to 48 weeks after baseline (Baseline is defined as the last week prior to Visit 14 (Randomization Visit) for the roll-over subjects and the last week prior to Visit 14 (Enrollment Visit) for de novo subjects).	Rescue medication usage (number of days used) during the Open Label Phase.
Summary of Change From Baseline in EuroQoL Group EQ-5D-5L Scores Over Time-Open Label Phase	48 weeks -From baseline to 48 weeks after baseline (Baseline is defined as the last week prior to Visit 14 (Randomization Visit) for the roll-over subjects and the last week prior to Visit 14 (Enrollment Visit) for de novo subjects).	Change from Open Label Titration baseline in EuroQol Group 5-dimension 5-level self-report questionnaire score in the Open Label Phase. The EuroQoL Group 5-Dimension 5-Level Self-Report Questionnaire (EQ-5D-5L) descriptive system is a generic, multidimensional, health-related, quality-of-life instrument. The profile allows subjects to rate their health state in 5 health domains: mobility, self-care, usual activities, pain/discomfort, and mood, using a 5-level scale. These combinations of attributes were converted into a weighted health-state index score, according to the US population-based algorithm, with higher scores indicating better quality of life. The score ranges from 0-100 with 0 as the worst health and 100 as the best health.
Summary of Change From Baseline in Clinical Global Impression of Improvement (CGI-I) Scale-Open Label	48 weeks -From baseline to 48 weeks after baseline (Baseline is defined as the last week prior to Visit 14 (Randomization Visit) for the roll-over subjects and the last week prior to Visit 14 (Enrollment Visit) for de novo subjects).	Summary of Change from Baseline in Clinical Global Impression of Improvement (CGI-I) scale. The Clinician Global Impression of Improvement (CGI-I) Scale is a 7-point scale that required the clinician to assess how much the subject's Pain had improved or worsened relative to the start of the study. Assessments were rated as: 1, very much improved; 2, much improved; 3, minimally improved; 4, no change; 5, minimally worse; 6, much worse; or 7, very much worse
Summary of Change From Baseline in Work Productivity and Activity Impairment Questionnaire (WPAI) Open Label Phase	48 weeks -From baseline to 48 weeks after baseline (Baseline is defined as the last week prior to Visit 14 (Randomization Visit) for the roll-over subjects and the last week prior to Visit 14 (Enrollment Visit) for de novo subjects).	Change from baseline in the Open Label Phase in Work Productivity and Activity Impairment score with a range of 0-100 for 4 types of scores with higher scores indicating greater impairment. The Work Productivity and Activity Impairment (WPAI) is a self-administered instrument used to measure the effect of general health and symptom severity on work productivity and regular activities, and yields 4 types of scores (higher scores indicate greater impairment): Absenteeism (work time missed)，Presenteeism (impairment at work/reduced on-the-job effectiveness), Work Productivity Loss (overall work impairment/absenteeism plus presenteeism)，and Activity Impairment. Scores range from 0-100 for each of the four types with higher scores indicating greater impairment.

Trial Locations

Locations (69): Aventiv Research, Inc.
🇺🇸
Columbus, Ohio, United States
International Clinical Research Institute Inc.
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Overland Park, Kansas, United States
Hassman Research Institute
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Berlin, New Jersey, United States
River Cities Clinical Research Center
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Shreveport, Louisiana, United States
Clinical Trials Research
🇺🇸
Lincoln, California, United States
Tampa Pain Relief Center-Brandon
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Brandon, Florida, United States
Lake Howell Health Center
🇺🇸
Maitland, Florida, United States
Boyett Health Services Inc
🇺🇸
Hamilton, Alabama, United States
MD Studies, Inc.
🇺🇸
Fountain Valley, California, United States
Florida Institute of Medical Research
🇺🇸
Jacksonville, Florida, United States
Catalina Research Institute, LLC
🇺🇸
Montclair, California, United States
Neuro-Pain Medical Center
🇺🇸
Fresno, California, United States
Gold Coast Research, LLC
🇺🇸
Plantation, Florida, United States
Allied Clinical Research, LLC
🇺🇸
Sacramento, California, United States
International Research Partners
🇺🇸
Doral, Florida, United States
New Phase Research & Development
🇺🇸
Knoxville, Tennessee, United States
Dr. Vijapura and Associates
🇺🇸
Jacksonville, Florida, United States
Otrimed
🇺🇸
Edgewood, Kentucky, United States
MedVadis Research Corporation
🇺🇸
Watertown, Massachusetts, United States
National Centers for Pain Management and Research
🇺🇸
Vestavia Hills, Alabama, United States
Non-Surgical Orthopedics, P.C.
🇺🇸
Marietta, Georgia, United States
Coastal Carolina Research Center
🇺🇸
Charleston, South Carolina, United States
Aspen Clinical Research
🇺🇸
Orem, Utah, United States
New York Clinical Trials, Inc
🇺🇸
New York, New York, United States
Medical Research South, LLC
🇺🇸
Charleston, South Carolina, United States
EPIC Medical Research
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Murray, Utah, United States
Scientific Clinical Research, Inc.
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North Miami, Florida, United States
River Birch Research Alliance LLC
🇺🇸
Blue Ridge, Georgia, United States
Phoenix Medical Research
🇺🇸
Prairie Village, Kansas, United States
Drug Studies America
🇺🇸
Marietta, Georgia, United States
Upstate Clinical Research Associates
🇺🇸
Williamsville, New York, United States
Columbus Regional Research Institute
🇺🇸
Knoxville, Georgia, United States
FMPM Research
🇺🇸
Saint Petersburg, Florida, United States
Amicis Trials
🇺🇸
Festus, Missouri, United States
FutureSearch Trials of Dallas, LP
🇺🇸
Dallas, Texas, United States
Millennium Pain Center
🇺🇸
Bloomington, Illinois, United States
Medisphere Medical Research Center
🇺🇸
Evansville, Indiana, United States
Suburban Research Associates
🇺🇸
Media, Pennsylvania, United States
Boston Paincare
🇺🇸
Waltham, Massachusetts, United States
Mid Columbia Research
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Richland, Washington, United States
Palm Beach Research Center
🇺🇸
West Palm Beach, Florida, United States
Clinical Research of West Florida-Tampa
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Tampa, Florida, United States
OnSite Clinical Solutions, LLC-Hickory
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Hickory, North Carolina, United States
Injury Care Research, LLC
🇺🇸
Boise, Idaho, United States
Frost Medical Group, LLC
🇺🇸
Conshohocken, Pennsylvania, United States
Tampa Pain Relief Centers-Hillsborough
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Tampa, Florida, United States
Dayton Outpatient Center (DOC) Clinical Research
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Dayton, Ohio, United States
Clinical Investigation Specialists, Inc.-Gurnee
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Gurnee, Illinois, United States
Rapha Institute for Clinical Research
🇺🇸
Fayetteville, North Carolina, United States
The SMART Clinic/Physicians Research Options LLC
🇺🇸
Draper, Utah, United States
The Pain Relief Center
🇺🇸
Plano, Texas, United States
Universal Pain Management Group
🇺🇸
Valencia, California, United States
Research Concepts GP, LLC-Houstion
🇺🇸
Houston, Texas, United States
Pioneer Research Solutions Inc.
🇺🇸
Houston, Texas, United States
Phoenix Clinical
🇺🇸
Phoenix, Arizona, United States
Noesis Pharma
🇺🇸
Phoenix, Arizona, United States
Arizona Research Center
🇺🇸
Phoenix, Arizona, United States
Care Practice
🇺🇸
San Francisco, California, United States
SP Research, PLLC
🇺🇸
Oklahoma City, Oklahoma, United States
Medical Research Internationl
🇺🇸
Oklahoma City, Oklahoma, United States
Parkway Medical Center
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Birmingham, Alabama, United States
Alliance Research Centers
🇺🇸
Laguna Hills, California, United States
Elite Clinical Studies
🇺🇸
Phoenix, Arizona, United States
Syrentis Clinical Research
🇺🇸
Santa Ana, California, United States
Ocean Blue Medical Research Center, Inc.
🇺🇸
Miami Springs, Florida, United States
MedEx Healthcare Research, Inc-NY
🇺🇸
New York, New York, United States
Center for Clinical Research, LLC-Winston-Salem
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Winston-Salem, North Carolina, United States
Providence Health Partners-Center for Clinical Research
🇺🇸
Dayton, Ohio, United States
Renaissance Clinical Research and Hypertension Clinic
🇺🇸
Dallas, Texas, United States