Control of post operative pain after lumbar spine surgery : Epidural dexmedetomidine versus clonidine as adjuvants to ropivacaine.
Not Applicable
Completed
- Conditions
- Health Condition 1: null- Patients with Lumbar PIVD, Lumbar vertebral fracture,lumbar spinal tumours.
- Registration Number
- CTRI/2017/10/010167
- Lead Sponsor
- IPGMER Hospital Kolkata
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 44
Inclusion Criteria
1.ASA physical status I/II
2.Age between 20yrs to 65 yrs.
3.Undergoing elective lumbar spine surgery
a)laminectomy ± discectomy.
b)Fracture fixation and instrumentation.
Exclusion Criteria
Patient refusal.
1.Known allergy to study drugs
2.Coagulopathies and platelet count <100000/cumm.
3.Significant systemic diseases.
4.Pre operative motor weakness and new onset post operative motor weakness.
5.Iatrogenic dural injury/tear
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Dexmedetomidine as an adjuvant, was associated with better analgesic parameters as compared to clonidine. <br/ ><br>Timepoint: VAS scores were checked every 5 mins for the first 30 mins and then every 30 mins for the next 8 hours. <br/ ><br> <br/ ><br>1. Onset of analgesia (VAS less than 4). <br/ ><br>2.Time taken to reach peak level of analgesia (VAS equals to 0). <br/ ><br>3.Duration of analgeisa (VAS more than 4). <br/ ><br> <br/ ><br>
- Secondary Outcome Measures
Name Time Method Dexmedetomidine has better haemodynamic profile as compared with clonidine, when administered via epidural route.Timepoint: Heart rate, SBP,DBP,MAP were recorded every 30 mins for 8 hours.;Motor block ( Bromage scale) for lower limbs.Timepoint: Every hour for 8 hours.;Nausea and vomitingTimepoint: Throughout the study duration.;Respiratory rateTimepoint: Every hour.;Sedation ( Ramsay Sedation Score).Timepoint: Every hour.