Epidural blockade affects the pharmacokinetics of propofol in surgical patients

Completed

• Conditions: The effect of epidural analgesia with ropivacaine on the pharmacokinetics and pharmacodynamics of propofol in patients; Surgery

• Registration Number: ISRCTN14865526
• Lead Sponsor: eiden University Medical Center (Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-01-30
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

1. American Society of Anesthesiologists (ASA) class I-II
2. Age 18-65 years
3. Patients scheduled for surgery requiring epidural anaesthesia and sedation

Exclusion Criteria

1. Patients with a body mass index (BMI) >30
2. Participation in a trial on investigational drugs within 3 months prior to the study
3. Known history of hepatic, renal disease or other disease as judged by the investigators
4. Bleeding or coagulation disorders
5. Patients receiving chronic analgesic therapy
6. Patients using alpha-blockers
7. Pregnancy or lactation
8. Alcohol or drug abuse or history of alcohol/drug abuse
9. Documented or suspected soybean protein and/or drug allergy
10. Allergy for amide-type local anesthetics

Study & Design

• Study Type: Interventional
• Study Design: Not specified