The influence of epidural blockade with ropivacaine on the pharmacokinetics and pharmacodynamics of propofol sedatio
Completed
- Conditions
- patienten die een epiduraal nodig hebben voor een operatieepidural analgesia
- Registration Number
- NL-OMON34206
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 28
Inclusion Criteria
•ASA class I-II
•Age 18-65 years
•Patients scheduled for surgery requiring epidural anaesthesia and sedation.
Exclusion Criteria
•Patients with a BMI >30.
•Participation in a trial on investigational drugs within 3 months prior to the study.
•Known history of hepatic, renal disease or other disease as judged by the investigators.
•Bleeding or coagulation disorders
Patients receiving chronic analgesic therapy.
•Patients using β-blockers
•Pregnancy or lactation.
•Alcohol or drug abuses or history of alcohol/drug abuses.
•Documented or suspected soybean protein and/or drug allergy or amide type local anesthetic allergy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>To evaluate the influence of epidural blockade with ropivacaine on the<br /><br>pharmacokinetics of propofol.<br /><br>To evaluate the influence of epidural blockade with ropivacaine on the<br /><br>pharmacodynamics of propofol. This includes both the sedative and the<br /><br>hemodynamic effects.</p><br>
- Secondary Outcome Measures
Name Time Method <p>hemodynamic parameters</p><br>