NCT02043405已完成不适用
Weight Loss and/or Exercise Training to Discover Muscle Lipids Related to Insulin Sensitivity.
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 2
- 主要终点
- Change in insulin sensitivity
研究概览
简要总结
The investigators will use exercise training and weight loss to discover localized lipid species related to diabetes risk in people.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Obese men and women with pre-diabetes; (BMI 30-40 kg/m2)
- •Ages ranging from 30-60 years old;
- •Individuals with:
- •impaired fasting glucose (IFG), (between 100-125mg/dl, with post-prandial glucose (<140 mg/dl 2 hrs after 75g OGTT)
- •impaired glucose tolerance (IGT), (normal fasting glucose <100mg/dl, with post-prandial glucose (>140 mg/dl 2 hrs after 75g OGTT)
- •a combination of the two (IFG/IGT) (both impaired fasting glucose (100-125mg/dl), and impaired glucose tolerance (>140 mg/dl 2 hrs after 75g OGTT), will be verified using oral glucose tolerance testing at initial screening, and
- •Sedentary (<2 hours/week of planned physical activity).
- •To increase generalizability, and because each subject serves as their own control, women will be enrolled regardless of menopausal status, use of hormone replacement therapy and oral contraceptives.
排除标准
- •Regular exercise more than 2 hours/week,
- •medications that could affect glucose,
- •lipid metabolism,
- •thyroid disease,
- •history of lung disease,
- •pregnancy,
- •active cigarette smoking or exposure to second hand smoke, and
- •Severe plasma lipid disorders.
结局指标
主要结局
Change in insulin sensitivity
时间窗: baseline and 3 months
Change in insulin sensitivity measured before and after the 3 month weight loss and exercise training intervention
次要结局
- Change in membrane localized diacylglycerol species(baseline and 3 months)
研究者
研究点 (2)
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