Dual Transversus Abdominis Plane Block in Pediatric Renal Transplant: Effect on Pain Control

Not Applicable

Completed

• Conditions: Renal Failure
• Interventions: Drug: bupivacaine; Drug: Pethidine; Drug: perfalgan; Drug: fentanyl

• Registration Number: NCT02858622
• Lead Sponsor: Cairo University

Brief Summary

Alleviating pain in children undergoing renal transplant is extremely challenging. Large incisions as those of renal transplant (Gibson's incision) require special techniques of pain control that don't affect hemodynamics or renal function. Since the transplant incision doesn't cross midline; a dual-TAP block is thought to be effective in providing pain control in such procedure as it will anesthetize the dermatomes T6-T12, the muscles of the anterior abdominal wall together with the underlying parietal peritoneum.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-04-05
• Study First Submitted QC: 2016-08-03
• Study First Posted: 2016-08-08
• Study Start: 2016-12
• Primary Completion: 2019-01
• Study Completion: 2019-03
• Status Verified: 2019-05
• Last Update Submitted: 2019-05-03
• Last Update Posted: 2019-05-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

• 3-16 years
• end stage renal disease
• no known allergy to bupivacaine
• both sexes

Exclusion Criteria

• known allergy to bupivacaine

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
dual TAB group	Pethidine	22 patients will receive unilateral dual transversus abdominis plane (TAB) block USING bupivacaine 0.25% at a dose of 2 mg/kg
dual TAB group	perfalgan	22 patients will receive unilateral dual transversus abdominis plane (TAB) block USING bupivacaine 0.25% at a dose of 2 mg/kg
control group	perfalgan	22 patients who will not receive dual TAB block
dual TAB group	bupivacaine	22 patients will receive unilateral dual transversus abdominis plane (TAB) block USING bupivacaine 0.25% at a dose of 2 mg/kg
control group	fentanyl	22 patients who will not receive dual TAB block
dual TAB group	fentanyl	22 patients will receive unilateral dual transversus abdominis plane (TAB) block USING bupivacaine 0.25% at a dose of 2 mg/kg
control group	Pethidine	22 patients who will not receive dual TAB block

Primary Outcome Measures

Name	Time	Method
total dose of rescue analgesia	from the time of transfer of the patient to the intensive care unit at one hour intervals for 24 hours	pethidine given as rescue analgesia postoperative.

Secondary Outcome Measures

Name	Time	Method
pain scoring system (objective behavioural pain score)	from the time of transfer to the nephrology ICU, every hour for the first 24 hours postoperative
Intraoperative blood pressure	from the induction of anesthesia till end of surgery at half an hour intervals average duration is 4 hours	measure systolic and diastolic blood pressure
postoperative heart rate	from the time of transfer of the patient to the intensive care unit at one hour intervals for 24 hours
intraoperative heart rate	from the induction of anesthesia till end of surgery at half an hour intervals average duration is 4 hours
postoperative blood pressure	from the time of transfer of the patient to the intensive care unit at one hour intervals for 24 hours	record systolic and diastolic blood pressure every hour for the first 24 hours postoperative

Trial Locations

Locations (1)

Faculty of medicine, Cairo University; 🇪🇬 Cairo, Egypt