The Role of HMGB-1 in Chronic Stroke
- Conditions
- Cerebral StrokeStroke, AcuteCerebrovascular Accident
- Registration Number
- NCT01705353
- Lead Sponsor
- Northwell Health
- Brief Summary
The purpose of this study is to measure the presence of HMGB-1 and other proteins in the blood across five time points after stroke, and to determine if their presence correlates with rate of stroke recovery.
- Detailed Description
Stroke, cerebrovascular accident, is the leading cause of brain injury and the leading cause of permanent disability. The acute pathophysiology of stroke depends on the innate immune response, which arises from mostly pro-inflammatory cascades. The chronic pathophysiology of stroke is less clear as the innate inflammatory response fades and matures into an adaptive immune response. HMGB-1 is a serum cytokine that has been found with persistent elevated levels for weeks to months after neurological insult in preclinical experiments, and may retard functional recovery. Elucidation of the relationship between HMGB-1 levels and the rate of functional recovery after stroke could lead to a better understanding of the systemic inflammatory response and more targeted therapeutic interventions.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 39
- Patients admitted to the stroke service at Northshore and LIJ Medical Centers
- Patients 18 years of age or older
- Patients < 18 years of age
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cytokine levels (HMGB-1) in plasma samples day 1, day7, day 14, day 30, day 90
- Secondary Outcome Measures
Name Time Method NIH and Rankin Clinical Measures of functional recovery day 1, day7, day 14, day 30, day 90
Trial Locations
- Locations (2)
Long Island Jewish Medical Center
🇺🇸New Hyde Park, New York, United States
North Shore University Hospital
🇺🇸Manhasset, New York, United States