NCT07625826尚未招募不适用
The Effect of Esketamine on Cough Reflex During Tracheal Extubation in Patients Undergoing Open Thyroid Surgery: A Randomized Controlled Study
The Second Hospital of Anhui Medical University1 个研究点 分布在 1 个国家目标入组 136 人开始时间: 2026年6月1日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 136
- 试验地点
- 1
研究概览
简要总结
This study intends to conduct a prospective randomized controlled trial to implement esketamine-assisted anesthesia in patients undergoing open thyroidectomy, in order to observe the effect of esketamine on coughing during extubation in thyroidectomy patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients scheduled for elective open thyroid surgery
- •ASA class I-II
- •Voluntarily participate in the study and sign the informed consent form
排除标准
- •Body Mass Index > 30 kg/m²
- •Patients with unstable ischemic cardiomyopathy, pulmonary hypertension, poorly controlled or untreated hypertension (arterial hypertension, resting systolic/diastolic blood pressure >180/100 mmHg)
- •Hepatic or renal dysfunction
- •History of oral, maxillofacial, neck, or airway surgery, or pathological structural alterations
- •Respiratory diseases (COPD, asthma, inflammation, chronic cough)
- •Patients with elevated intracranial pressure
- •Patients undergoing repeat surgery
- •History of allergy to the investigational drug used in the study
- •Patients with psychiatric disorders or alcohol abuse (daily ethanol intake ≥40 g, or having experienced alcohol withdrawal within the past 6 months, or unable to control alcohol consumption)
研究者
Yun Wu
Doctor, Anesthesiology
The Second Hospital of Anhui Medical University
研究点 (1)
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