remic Toxins, Cardiovascular Effects and Physical Activity in Intensive Hemodialysis

Completed

• Conditions: end-stage renal disease; 10046590

• Registration Number: NL-OMON39123
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 140

Inclusion Criteria

-Incident and prevalent conventional hemodialysis (CHD), intensive HD [short daily hemodialysis (SDHD), nocturnal hemodialysis (NHD) and home nocturnal hemodialysis (HNHD)] and peritoneal dialysis (PD) patients
-Different patient groups (CHD, intensive HD and PD) will be matched according to transplantation candidature en Charlson Comorbidity Index
-Standard renal diet (80 g of protein per day)
-Age > 18 years
-Informed consent

Exclusion Criteria

-Charlson risk index of 5 or higher
-Chronic antibiotic use and colectomy because of interference with uremic toxin formation and degradation
-Withdrawal of consent
-For bio-impedance measurements: presence of ICD or pacemaker. There are no restrictions for other measurements in these patients.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>-Pulse wave velocity</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-Levels of uremic toxins<br /><br>-Physical activity</p><br>