Effects of sildenafil on the pulmonary microvascular disease of symptomatic smoker
- Conditions
- Tobacco usedyspneaZ72.0C08.618.326
- Registration Number
- RBR-9t6rd7
- Lead Sponsor
- niversidade Federal de Mato Grosso do Sul
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- Not specified
- Target Recruitment
- Not specified
Symptomatic vascular phenotype; Individuals of both sexes; Age between 35 and 80 years; History of smoking for more than 10 years; Sinus rhythm; Preserved left ventricular ejection fraction (higher than 50%); The evaluated patients should be able to perform spirometry, carbon monoxide diffusion test and cardiopulmonary exercise test.
Carrier of diabetes mellitus, bronchial asthma, previous myocardial infarction, heart failure, complex ventricular arrhythmias; Chronic atrial fibrillation; Body mass index lower than 18.5 or higher than 35 kg per m²; Anemia with hemoglobin lower than 11 g% in women and lower than 12 g% in men; Chronic hypoxemia of undetermined cause; neuromuscular, orthopedic or psychological limitation;
Contraindication to the use of sildenafil citrate or previous use of it thereof.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method