Staphylococcus Aureus Bacteraemia (SAB)-Support-Study

Not Applicable

Recruiting

• Conditions: Staphylococcus Aureus Bacteremia
• Interventions: Other: Checklist-based phone calls

• Registration Number: NCT06249451
• Lead Sponsor: University Medicine Greifswald

Brief Summary

The main objective of this study is to investigate whether checklist-based close telephone consultation and process surveillance for S. aureus bacteraemia (SAB) can improve adherence to our in-house SAB-guidelines (prospective quality- improvement group).

In addition, the effects of telephone consultation on the clinical outcome of patients will be examined.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-01
• Study First Submitted: 2024-01-19
• Study Start: 2024-01-22
• Study First Submitted QC: 2024-01-31
• Last Update Submitted: 2024-01-31
• Study First Posted: 2024-02-08
• Last Update Posted: 2024-02-08
• Primary Completion: 2025-01-22
• Study Completion: 2025-04-23

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 124

Inclusion Criteria

• ≥ 18 years
• Inpatient treatment at the University Medicine Greifswald university hospital
• First diagnosis of SAB in hospital

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Exclusion Criteria

• SAB already known before admission
• Palliative management within 48 hrs after SAB diagnosis
• Death within 48 hrs after SAB diagnosis
• Hospital discharge within 48hrs after SAB diagnosis

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Arm && Interventions

Group	Intervention	Description
Prospective quality-improvement group (n= 62)	Checklist-based phone calls	Analysis of patients with the diagnosis of S. aureus-bacteraemia between 22.01.2024-22.01.2025

Primary Outcome Measures

Name	Time	Method
SOP adherence, calculated as a sum score per patient with the following 8 parameters:	Hospital admission until hospital discharge (no later than day 90 after diagnosis)	1. Drawing of follow-up blood cultures 2-3 days after start of adequate antibiotic therapy; 2. Early source control (removal of infected material or drainage of an abscess ≤ 72 hrs); 3. Adequate search for SAB focus and metastatic manifestations; 4. TEE in patients with clinical indications (within 4 days of SAB diagnosis); 5. Early start of specific therapy after receipt of results via phone call (≤12 hrs); 6. Adequate dosage of antibiotic; 7. Sufficient duration of therapy (at least 14 d for uncomplicated bacteremia and 28 d for complicated bacteremia); 8. Combination therapy with Rifampicin or Fosfomycin, when indicated

Secondary Outcome Measures

Name	Time	Method
Time to specific antimicrobial treatment according to guidelines concerning agent and duration	Hospital admission until hospital discharge (no later than day 90 after diagnosis)
Time to negativity of follow up blood cultures	Day of SAB diagnosis until hospital discharge (no later than day 90 after diagnosis)
Time till TEE is performed (when indicated)	Hospital admission until hospital discharge (no later than day 90 after diagnosis)
Length of hospital stay after SAB diagnosis	Day of SAB diagnosis until hospital discharge (no later than day 90 after diagnosis)
In-hospital mortality (all patients)	Hospital admission until hospital discharge (no later than day 90 after diagnosis)
In-hospital mortality (because of SAB complications)	Hospital admission until hospital discharge (no later than day 90 after diagnosis)
Hospital readmission until day 90 after SAB diagnosis (all patients)	Day of SAB diagnosis until day 90 after diagnosis
90-day mortality because of SAB complications	Day of SAB diagnosis until day 90 after diagnosis
Hospital readmission until day 30 after SAB diagnosis (all patients)	Day of SAB diagnosis until day 30 after diagnosis
Hospital readmission until day 30 after SAB diagnosis (because of SAB complications)	Day of SAB diagnosis until day 30 after diagnosis
Relapse of bacteremia until day 90 after diagnosis	Day of SAB diagnosis until day 90 after diagnosis
Hospital readmission until day 90 after SAB diagnosis (because of SAB complications)	Day of SAB diagnosis until day 90 after diagnosis
90-day all-cause mortality	Day of SAB diagnosis until day 90 after diagnosis
Quality of discharge summary (documentation and treatment plan), calculated as a sum score	Hospital admission until hospital discharge (no later than day 90 after diagnosis)
Infectious diseases consultation, when indicated (yes/no)	Hospital admission until hospital discharge (no later than day 90 after diagnosis)

Trial Locations

Locations (1)

Greifswald University Medicine; 🇩🇪 Greifswald, Germany