Effects of long-term gonadotropin-releasing hormone agonist treatment on the pregnancy outcome of IVF-ET in infertile patients with endometriosis.
Not Applicable
- Conditions
- endometriosis
- Registration Number
- JPRN-UMIN000007486
- Lead Sponsor
- Yamaguchi University Graduate School of Medicine
- Brief Summary
The numbers of mature follicles and retrieved oocytes, and fertilization rates did not differ between the two groups. Implantation rates and pregnancy rates tended to be higher in the UL group compared with the C group. TNFa and 8OHdG concentrations in the follicular fluid were significantly lower in the UL group than those in the C group, while melatonin concentrations were significantly higher in the UL group compared with the C group.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Female
- Target Recruitment
- 23
Inclusion Criteria
Not provided
Exclusion Criteria
Patients were nonsmokers and free from major medical illness including hypertension. Patients were excluded if they had myoma, adenomyosis, a congenital uterine anomaly, or if they used any kind of sex-steroidal agent including estrogens, progesterone, androgens, and OC.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method pregnancy rate
- Secondary Outcome Measures
Name Time Method number of growing follicle, mature follicle and oocyte retrieved. fertilization rate implantation rate concentrations of cytokines and oxidative stress markers in follicular fluids.