Chronic inflammation and development of cancer in the esophagus

Completed

• Conditions: Chronic reflux disease; heart burn; 10017990; 10017991

• Registration Number: NL-OMON30962
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

- >= 18 years old
- written informed consent
- upper or lower gastrointestinal tract endoscopy for diagnosis or follow-up of pre-malignant disorder of the gastrointestinal tract

Exclusion Criteria

- pregnancy
- esophagectomy, gastrectomy
- total proctocolectomy

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is a significant difference in the number and type of<br /><br>DCs in the esophagus of patients with chronic gastro esophageal reflux disease<br /><br>and BE. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- To determine DC populations in blood<br /><br>- To relate the above-mentioned findings of DC to other pre-malignant<br /><br>gastrointestinal disorders, i.e., Crohn*s disease and ulcerative colitis.</p><br>