Results of Postoperative Analgesis Protocols Applied in Total Knee Arthroplasty:Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Postoperative pain
研究概览
简要总结
Postoperative analgesic treatment methods are applied to patients who have undergone knee arthroplasty. These applications are a routine part of the procedure. It is medically and ethically necessary. Postoperative analgesia applications are started during the intraoperative period and continued during the postoperative period. The analgesia protocol to be used is shaped by the characteristics of the patient and the skill and experience of the anesthesiologist. The scientifically accepted method is multimodel analgesia protocols. These protocols cover a wide range from paracetamol to opioids to peripheral and central blocks (methods such as suprainguinal fascia iliac block (SFIP), adductor block (ACB) and infiltration analgesia (IPACK) applied between the posterior elements of the knee and the popliteal artery). Our aim in this study is to evaluate the effects of analgesia protocols applied to patients undergoing knee arthroplasty surgery on inflammatory biomarkers (such as neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), systemic immune inflammation score (SII), lactate) obtained from routine blood and blood gas examinations in the first 24 hours of the postoperative period.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18-75 years old
- •ASA I,II,III patients
- •Patients who will undergo elective surgery
排除标准
- •Patients undergoing emergency surgery
- •Patients with bleeding diathesis
- •Those who are allergic or sensitive to local anesthetics and opioid drugs,
- •Those who use gabapentinoids
- •Patients with neurocognitive disorders,
- •Patients with chronic organ failure,
- •Mothers with suspected pregnancy, pregnant or breastfeeding mothers
- •Patients using opioids
- •Those who use steroids
- •Those with a history of substance use
结局指标
主要结局
Postoperative pain
时间窗: postoperative 24 hours
Pain levels of patients will be evaluated with the Numerical Pain Scale (NRS) in the first 24 hours postoperatively.
次要结局
- inflammatory mediators(preoperative 24 hours)
研究者
Senay Canikli
MD
Samsun University
