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临床试验/NCT06498557
NCT06498557已完成不适用

Results of Postoperative Analgesis Protocols Applied in Total Knee Arthroplasty:Observational Study

Senay Canikli1 个研究点 分布在 1 个国家目标入组 70 人开始时间: 2024年7月22日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
70
试验地点
1
主要终点
Postoperative pain

研究概览

简要总结

Postoperative analgesic treatment methods are applied to patients who have undergone knee arthroplasty. These applications are a routine part of the procedure. It is medically and ethically necessary. Postoperative analgesia applications are started during the intraoperative period and continued during the postoperative period. The analgesia protocol to be used is shaped by the characteristics of the patient and the skill and experience of the anesthesiologist. The scientifically accepted method is multimodel analgesia protocols. These protocols cover a wide range from paracetamol to opioids to peripheral and central blocks (methods such as suprainguinal fascia iliac block (SFIP), adductor block (ACB) and infiltration analgesia (IPACK) applied between the posterior elements of the knee and the popliteal artery). Our aim in this study is to evaluate the effects of analgesia protocols applied to patients undergoing knee arthroplasty surgery on inflammatory biomarkers (such as neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), systemic immune inflammation score (SII), lactate) obtained from routine blood and blood gas examinations in the first 24 hours of the postoperative period.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 75 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • 18-75 years old
  • ASA I,II,III patients
  • Patients who will undergo elective surgery

排除标准

  • Patients undergoing emergency surgery
  • Patients with bleeding diathesis
  • Those who are allergic or sensitive to local anesthetics and opioid drugs,
  • Those who use gabapentinoids
  • Patients with neurocognitive disorders,
  • Patients with chronic organ failure,
  • Mothers with suspected pregnancy, pregnant or breastfeeding mothers
  • Patients using opioids
  • Those who use steroids
  • Those with a history of substance use

结局指标

主要结局

Postoperative pain

时间窗: postoperative 24 hours

Pain levels of patients will be evaluated with the Numerical Pain Scale (NRS) in the first 24 hours postoperatively.

次要结局

  • inflammatory mediators(preoperative 24 hours)

研究者

发起方
Senay Canikli
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Senay Canikli

MD

Samsun University

研究点 (1)

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Postoperative Analgesis in Total Knee Arthroplasty | 临床试验