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Clinical Trials/NCT06498557
NCT06498557
Completed
Not Applicable

Results of Postoperative Analgesis Protocols Applied in Total Knee Arthroplasty:Observational Study

Senay Canikli1 site in 1 country70 target enrollmentJuly 22, 2024

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Knee Arthroplasty
Sponsor
Senay Canikli
Enrollment
70
Locations
1
Primary Endpoint
Postoperative pain
Status
Completed
Last Updated
last year

Overview

Brief Summary

Postoperative analgesic treatment methods are applied to patients who have undergone knee arthroplasty. These applications are a routine part of the procedure. It is medically and ethically necessary. Postoperative analgesia applications are started during the intraoperative period and continued during the postoperative period. The analgesia protocol to be used is shaped by the characteristics of the patient and the skill and experience of the anesthesiologist. The scientifically accepted method is multimodel analgesia protocols. These protocols cover a wide range from paracetamol to opioids to peripheral and central blocks (methods such as suprainguinal fascia iliac block (SFIP), adductor block (ACB) and infiltration analgesia (IPACK) applied between the posterior elements of the knee and the popliteal artery). Our aim in this study is to evaluate the effects of analgesia protocols applied to patients undergoing knee arthroplasty surgery on inflammatory biomarkers (such as neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), systemic immune inflammation score (SII), lactate) obtained from routine blood and blood gas examinations in the first 24 hours of the postoperative period.

Registry
clinicaltrials.gov
Start Date
July 22, 2024
End Date
October 5, 2024
Last Updated
last year
Study Type
Observational
Sex
All

Investigators

Sponsor
Senay Canikli
Responsible Party
Sponsor Investigator
Principal Investigator

Senay Canikli

MD

Samsun University

Eligibility Criteria

Inclusion Criteria

  • 18-75 years old
  • ASA I,II,III patients
  • Patients who will undergo elective surgery

Exclusion Criteria

  • Patients undergoing emergency surgery
  • Patients with bleeding diathesis
  • Those who are allergic or sensitive to local anesthetics and opioid drugs,
  • Those who use gabapentinoids
  • Patients with neurocognitive disorders,
  • Patients with chronic organ failure,
  • Mothers with suspected pregnancy, pregnant or breastfeeding mothers
  • Patients using opioids
  • Those who use steroids
  • Those with a history of substance use

Outcomes

Primary Outcomes

Postoperative pain

Time Frame: postoperative 24 hours

Pain levels of patients will be evaluated with the Numerical Pain Scale (NRS) in the first 24 hours postoperatively.

Secondary Outcomes

  • inflammatory mediators(preoperative 24 hours)

Study Sites (1)

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