The effect of adding N-acetylcysteine ??to the usual treatments of schizophrenia in improving the symptoms in patients referred to the ward and clinic of Khorshid Hospital in 1401

Phase 1

Recruiting

Conditions: Patients with schizophrenia who have undergone an acute phase.
Schizophrenia

Registration Number: IRCT20201119049445N2

Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 70

Inclusion Criteria

Patients with schizophrenia between the ages of 19 and 65 who have undergone the acute phase (the onset of the acute phase is assessed by a psychiatrist and the project resident)
Diagnosis of schizophrenia based on DSM 5 criteria by a psychiatrist
Have at least five classes of education

Exclusion Criteria

Pregnancy and lactation
Substance abuse
Severe physical illness
Contraindications to the use of N-acetylcysteine
Existence of intellectual disability
Receive ECT 6 months before or during the study
Patients treated with nitroglycerin
Patients treated with insulin
Patients treated with chloroquine
Patients treated with more than 200 mg of selenium
Patients treated with anticoagulants except aspirin and NSAIDs

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improve cognitive function. Timepoint: Before the start of the study and 4, 8 weeks after taking N-acetylcysteine. Method of measurement: Average total score of NUCOG questionnaire and its areas.;Improve the negative symptoms of schizophrenia. Timepoint: Before the start of the study and 4, 8 weeks after taking N-acetylcysteine. Method of measurement: Scale for the Assessment of negative Symptoms.;Improve the positive symptoms of schizophrenia. Timepoint: Before the start of the study and 4, 8 weeks after taking N-acetylcysteine. Method of measurement: Scale for the Assessment of Positive Symptoms.

Secondary Outcome Measures

Name	Time	Method
Peripheral blood glutathione leve. Timepoint: Before the intervention and two months after the intervention. Method of measurement: Blood sampling and measurement of glutathione levels with glutathione assy kit.