The effect of N-acetyl cysteine on platelet aggregation in splenectomized non-transfusion dependent thalassemia patients

Phase 3

Recruiting

• Conditions: Beta thalassemia.; Beta thalassemia; D56.1

• Registration Number: IRCT20100110003032N4
• Lead Sponsor: Mazandaran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 13 November 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Beta thalassemia
Non-transfusion dependent
Splenectomy
Age above 18 years
Under Aspirin therapy

Exclusion Criteria

Age less than 18 years
Simultaneous consumption of other antioxidants such as vitamin C and E
Diabetes
Irregular use of N-acetylcysteine

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reduction of at least 50% in anticoagulation panel. Timepoint: At the beginning of the study, one month later and the end of the second month. Method of measurement: Laboratory tests including: Factor V Leiden; c and s proteins; antithrombin 3; Lupus Anticoagulant.

Secondary Outcome Measures

Name	Time	Method
Factor V Leiden. Timepoint: Upon entering the study, 1 month and 2 months later. Method of measurement: Blood test.;C and S protein. Timepoint: Upon entering the study, 1 month and 2 months later. Method of measurement: Blood test.;Antithrombin 3. Timepoint: Upon entering the study, 1 month and 2 months later. Method of measurement: Blood test.;Lupus anticoagulant. Timepoint: Upon entering the study, 1 month and 2 months later. Method of measurement: Blood test.