Rate Control in Atrial Fibrillation

Phase 4

Completed

• Conditions: Rapid Ventricular Response Atrial Fibrillation
• Interventions: Drug: Metoprolol; Drug: Verapamil; Drug: Propranolol; Drug: Diltiazem

• Registration Number: NCT01655303
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Rate control in atrial fibrillation is a usual battle in emergency departments. Oral medications have a natural superiority to intravenous ones because they are easy-to-use and decrease the workload in busy emergency departments.

This study wants to find an effective oral medication for rate control in rapid ventricular response atrial fibrillation. Propranolol and Metoprolol, Diltiazem and Verapamil are compared in patients with a stable hemodynamic status.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-02
• Primary Completion: 2011-12
• Study Completion: 2011-12
• Status Verified: 2012-07
• Study First Submitted: 2012-07-30
• Study First Submitted QC: 2012-07-30
• Last Update Submitted: 2012-07-30
• Study First Posted: 2012-08-01
• Last Update Posted: 2012-08-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Age more than 18 years old
• Stability in hemodynamic

Exclusion Criteria

• Systolic blood pressure less than 90 mm Hg
• Altered mental status attributable to rapid ventricular response atrial fibrillation
• Acute pulmonary edema attributable to rapid ventricular response atrial fibrillation
• Chest pain attributable to rapid ventricular response atrial fibrillation
• Allergy to Propranolol or Metoprolol or Verapamil or Diltiazem
• History of asthma

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Metoprolol Per Oral	Metoprolol	50 mg Metoprolol
Verapamil	Verapamil	40 mg Verapamil Per Oral
Propranolol	Propranolol	40 mg Propranolol Per Oral
Diltiazem	Diltiazem	60 mg Diltiazem Per Oral

Primary Outcome Measures

Name	Time	Method
Rate less than 100 per minute	In 1 hour	Ventricular rate less than 100 per minute after 1 hour of per oral medication administration

Secondary Outcome Measures

Name	Time	Method
Drugs adverse effects	2 hours	Drugs adverse effects seen in patients in 2 hours after per oral medication administration
Unstability in hemodynamic	2 hours	Hemodynamic instability (systolic blood pressure less than 90 mmHg, loss of consciousness, pulmonary edema, chest pain)

Trial Locations

Locations (1)

Rasoul-e-Akram Hospital; 🇮🇷 Tehran, Iran, Islamic Republic of