Oral Propranolol, Diltiazem, Metoprolol and Verapamil in Atrial Fibrillation Rate Control in Patients With Stable Hemodynamic Status
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Rate less than 100 per minute
研究概览
简要总结
Rate control in atrial fibrillation is a usual battle in emergency departments. Oral medications have a natural superiority to intravenous ones because they are easy-to-use and decrease the workload in busy emergency departments.
This study wants to find an effective oral medication for rate control in rapid ventricular response atrial fibrillation. Propranolol and Metoprolol, Diltiazem and Verapamil are compared in patients with a stable hemodynamic status.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age more than 18 years old
- •Stability in hemodynamic
排除标准
- •Systolic blood pressure less than 90 mm Hg
- •Altered mental status attributable to rapid ventricular response atrial fibrillation
- •Acute pulmonary edema attributable to rapid ventricular response atrial fibrillation
- •Chest pain attributable to rapid ventricular response atrial fibrillation
- •Allergy to Propranolol or Metoprolol or Verapamil or Diltiazem
- •History of asthma
研究组 & 干预措施
Propranolol
40 mg Propranolol Per Oral
干预措施: Propranolol (Drug)
Verapamil
40 mg Verapamil Per Oral
干预措施: Verapamil (Drug)
Metoprolol Per Oral
50 mg Metoprolol
干预措施: Metoprolol (Drug)
Diltiazem
60 mg Diltiazem Per Oral
干预措施: Diltiazem (Drug)
结局指标
主要结局
Rate less than 100 per minute
时间窗: In 1 hour
Ventricular rate less than 100 per minute after 1 hour of per oral medication administration
次要结局
- Drugs adverse effects(2 hours)
- Unstability in hemodynamic(2 hours)