The effect of melatonin on inflammatory cytokines in patients undergoing coronary artery bypass graft surgery

Phase 2

• Conditions: Coronary Artery Bypass Surgery.; Atherosclerotic heart disease of native coronary artery; I25.1

• Registration Number: IRCT20141009019470N73
• Lead Sponsor: Shiraz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 February 2020

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

Patients who are candidate for elective CABG with age between 40-75 years old and ASA class <III; pump time less than 90 min; graft number between 2 to 6.

Exclusion Criteria

pregnancy and breast feeding; local or systemic infection; hyper sensitivity; redo surgery; surgery during last 6 months; collagen vascular disease; immunosuppressive disease; heart failure with ejection fraction less than 35%; recent cardiovascular event; un controlled HTN; renal failure; liver failure; alcohol abuser; malignancy; simultaneously valvular heart surgery.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum level of Inflammatory cytokines. Timepoint: Two weeks before administration of melatonin, in the operating room before induction of anesthesia, 6 hours after declamping in the ICU and 48 hours after off pump. Method of measurement: venous blood samples.