Event-related Potentials in Management of Children With Attention-deficit/Hyperactivity Disorder
试验速览
- 阶段
- 不适用
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Chinese version of SNAP-IV Rating Scale
研究概览
简要总结
The investigators try to objectively and scientifically explore various brain function impairments in ADHD children by electrophysiologic tests, with and without medication.
详细描述
The aims of this study are to explore the various cognitive impairments of ADHD children, to differentiate various subtypes of ADHD children, and to investigate the efficacy of anti-ADHD drugs on various cognitive performance of ADHD children by event-related potentials(ERP).
Children, aged six to 18 years old, are enrolled and assigned to three groups (normal control, pure ADHD, and ADHD with comorbidities). ADHD children fulfill the DSM-IV-TR criteria for the diagnosis of ADHD. ADHD children are evaluated by Chinese version of SNAP-IV Rating Scale for rating ADHD-related symptoms before and after medication. EEG and audiometric testing are required for every participant to exclude dialeptic seizures and hearing impairment respectively.
Methylphenidate (either immediate-release or extended-release formulations) or atomoxetine Hydrochloride is given to ADHD participants.Continuous performance task (CPT) and ERP tasks are applied.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •health children
- •or clinical diagnosis of attention-deficit hyperactivity disorder
排除标准
- •hearing impairment
- •uncorrectable visual impairment
研究组 & 干预措施
pure ADHD
干预措施: Atomoxetine (Drug)
pure ADHD
干预措施: methylphenidate (Drug)
pure ADHD
干预措施: behavioral modification (Behavioral)
ADHD with comorbidity
干预措施: methylphenidate (Drug)
ADHD with comorbidity
干预措施: Atomoxetine (Drug)
ADHD with comorbidity
干预措施: behavioral modification (Behavioral)
结局指标
主要结局
Chinese version of SNAP-IV Rating Scale
时间窗: 8 weeks
次要结局
- Event-related potential(8 weeks)