L-PRF vs PBM on Extraction Socket Healing

Not Applicable

Completed

• Conditions: Healing Surgical Wounds; Pain
• Interventions: Device: photobiomodulation; Other: Leukocyte and Platelet Rich Fibrin

• Registration Number: NCT06328413
• Lead Sponsor: Akdeniz University

Brief Summary

The aim of this study is to compare leukocyte and platelet-rich fibrin (L-PRF) and photobiomodulation (PBM) applications, which have been repeatedly reported to be superior to control groups, in terms of pain, soft tissue and bone healing in tooth extraction sockets.

Detailed Description

After sample size calculation, healthy volunteers were included in the study. Both teeth of these individuals with bilaterally impacted wisdom teeth were extracted simultaneously. Photobiomodulation (PBM) or leukocyte and platelet rich fibrin (L-PRF), an autogenous blood product, was randomly applied to the right or left side extraction sockets. Volunteers were called for repeat sessions (days 2,4,7,7,11,11,14,18 and 21) for the PBM treated side. Follow-ups were performed for pain (days 2,4,7) and soft and bone tissue healing.

Study Timeline

• Study Start: 2020-04-20
• Primary Completion: 2021-06-21
• Study Completion: 2021-09-21
• Status Verified: 2024-03
• Study First Submitted: 2024-03-11
• Study First Submitted QC: 2024-03-21
• Last Update Submitted: 2024-03-21
• Study First Posted: 2024-03-25
• Last Update Posted: 2024-03-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• American Society of Anesthesiologists (ASA) Class-I healthy volunteers
• Between 18 and 40 years of age who had wisdom teeth (Pell and Gregory Class II, Position B) with bone retention in bilateral symmetrical position with an indication for extraction, and had second molars in the mouth,
• Not use steroids or anti-inflammatory drugs in the last 3 months.

Exclusion Criteria

• Patients with pericoronitis,
• Smoking habits
• Active periodontal disease
• Pregnancy,
• Breastfeeding
• Unable to give personal consent, and those with missing physical examination and follow-up records were excluded.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Photobiomodulation group	photobiomodulation	Photobiomodulation application at different extra and intraoral points for 60 seconds with a wavelength of 940 nm in repeated sessions after the extraction of third molar
Leukocyte and platelet-rich fibrin group	Leukocyte and Platelet Rich Fibrin	Leukocyte and platelet rich fibrin ( blood product centrifuged for 12 minutes at 2700rpm) application after third molar extraction, single session.

Primary Outcome Measures

Name	Time	Method
Newly formed bone (Healing at extraction sockets)	Bone healing at the end of 1st and 3rd months after third molar extractions	Newly formed bone assessed on Panoramic x-ray with Image J programme

Secondary Outcome Measures

Name	Time	Method
Soft tissue healing	End of 1st, 2nd week and 1st month after tooth extraction	Landry Index scores (1: Very poor, 2: Poor, 3: Good, 4. Very Good, 5. Excellent healing)
Probing depth	End of 1st, 2nd week and 1st month after tooth extraction	Probing depth of second mandibular molar distal pocket (millimeters)

Trial Locations

Locations (1)

Akdeniz University; 🇹🇷 Antalya, Merkez, Turkey