Study Comparing CT Scan and Stress Test in Patients With Known Coronary Artery Disease Hospitalized for Chest Pain

Not Applicable

Terminated

• Conditions: Acute Coronary Syndrome; Coronary Artery Disease; Angina Pectoris; Unstable Angina
• Interventions: Procedure: Coronary CT angiography; Procedure: Myocardial perfusion imaging

• Registration Number: NCT01106612
• Lead Sponsor: Montefiore Medical Center

Brief Summary

The purpose of this study is to determine whether coronary artery CT scanning or nuclear stress testing is better at diagnosing chest pain patients with known coronary artery disease to select appropriate candidates for coronary catheterization and re-vascularization.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-04
• Study First Submitted: 2010-04-12
• Study First Submitted QC: 2010-04-19
• Study First Posted: 2010-04-20
• Primary Completion: 2013-12
• Study Completion: 2013-12
• Status Verified: 2015-04
• Last Update Submitted: 2015-04-07
• Last Update Posted: 2015-04-08

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 7

Inclusion Criteria

• patient admitted for chest pain / pressure or other suggestive symptoms
• patient has known coronary artery disease (with or without prior revascularization)
• patient has clinical need for non-invasive cardiac evaluation

Exclusion Criteria

• evidence of ongoing myocardial infarction or hemodynamic instability
• ischemia on EKG (greater than 1mm ST segment deviation)
• contraindications to CT scanning with iodinated intravenous contrast (including allergies, asthma and renal dysfunction)
• heart rhythm precluding EKG gating
• pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Initial coronary CT angiography	Coronary CT angiography	EKG-gated, computed tomography angiography of the coronary arteries during heart rate control
Initial nuclear stress test	Myocardial perfusion imaging	Stress radionuclide myocardial perfusion imaging

Primary Outcome Measures

Name	Time	Method
Number of participants that undergo subsequent cardiac catheterization but do not have consequent coronary angioplasty, stenting or bypass	3 months

Secondary Outcome Measures

Name	Time	Method
Number of participants that have a subsequent non-fatal myocardial infarction	1 year
Number of participants that experience a procedural complication due to non-invasive imaging, cardiac catheterization or coronary revascularization	3 months
Length of hospital stay (time to discharge)	1 month
Number of participants that die due to any cause	1 year

Trial Locations

Locations (1)

Montefiore Medical Center; 🇺🇸 Bronx, New York, United States