Study Comparing CT Scan and Stress Test in Diagnosing Coronary Artery Disease in Patients Hospitalized for Chest Pain

Not Applicable

Completed

• Conditions: Coronary Artery Disease; Unstable Angina; Angina Pectoris; Acute Coronary Syndrome
• Interventions: Procedure: Coronary Computed Tomography Angiography; Procedure: Stress Nuclear Myocardial Perfusion Imaging

• Registration Number: NCT00705458
• Lead Sponsor: Montefiore Medical Center

Brief Summary

The purpose of this study is to determine whether coronary artery CT scanning or nuclear stress testing is better at diagnosing chest pain patients with coronary artery disease to select appropriate candidates for coronary catheterization and re-vascularization.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2008-06-24
• Study First Submitted QC: 2008-06-24
• Study First Posted: 2008-06-26
• Study Start: 2008-07
• Primary Completion: 2013-03
• Study Completion: 2013-12
• Status Verified: 2015-08
• Last Update Submitted: 2015-08-21
• Last Update Posted: 2015-08-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

• patient admitted for chest pain or pressure
• patient at intermediate short term risk of MI or death (AHA/ACC guidelines)

Exclusion Criteria

• prior diagnosis of coronary artery disease
• evidence of ongoing myocardial infarction (and other high risk criteria per AHA/ACC guidelines)
• contraindications to EKG-gated CT scanning with iodinated intravenous contrast under beta-blockade
• pregnancy
• presence of an implanted pacemaker or defibrillator
• stress myocardial perfusion imaging, coronary CTA or coronary catheterization within the last 6 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
CTA	Coronary Computed Tomography Angiography	Initial EKG-gated computed tomography angiography of the coronary arteries
MPI	Stress Nuclear Myocardial Perfusion Imaging	Initial nuclear stress myocardial perfusion imaging

Primary Outcome Measures

Name	Time	Method
Coronary catheterization that does not lead to re-vascularization	1 year

Secondary Outcome Measures

Name	Time	Method
Post-test renal dysfunction	usually within a few days
Death (all cause)	1 year
Length of Hospital Stay (time to discharge)	usually from hours to a few days (average about one day)
Non-fatal myocardial infarction	1 year

Trial Locations

Locations (1)

Moses Division, Montefiore Medical Center; 🇺🇸 Bronx, New York, United States