Induction and Recognition of Emotions in Healthy Older Adults, Alzheimer's Disease and Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Spanish-Complutense Verbal Learning Test (TAVEC)
研究概览
简要总结
This study evaluates the differences in cognitive function between healthy older adults, older adults with mild Alzheimer's type dementia and older adults with Parkinson's disease and if there are differences in valence assessment and activation that produce them a mood induction task. Subjects are assessed using neuropsychological tests and then a mood induction task based on movie clips is applied.
详细描述
Different neuropsychological tests will be used to assess the differences in cognitive function in the different groups, whose scores are expected to be lower in the group of older adults with Alzheimer's disease (AD) and older adults with Parkinson's disease (PD).
After studying the cognitive function in the different groups, we proceed to check through a task based on movie clips if there are also differences in the valence assessment (liking/disliking depending on the emotion induced by scenes from different films) and activation (excitement caused by each one of the movie scenes), hoping to find differences for the negative emotions taking into account the cognitive difficulties that both (the EA group and the EP group) may have for processing this type of cognitively more demanding information; instead, it is possible that the positivity effect continues to affect these patients so that for positive emotions there are no differences between the different groups.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 65 Years 至 99 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For the group of healthy older adults:
- •MEC score greater than 26 points.
- •GDS between 1 and
- •For the mild EA group:
- •MEC score between 18 and 23 points.
- •GDS between 3 and
- •For the EP group:
- •MEC score greater than 23 points.
- •GDS between 1 and
- •FAB score equal to or less than 11 points.
排除标准
- •Participants cannot have:
- •Significant asymptomatic neurovascular disease
- •History of previous symptomatic stroke
- •Alcohol or drug abuse/dependence
- •Severe psychiatric symptoms
- •Depressive symptoms higher than mild
结局指标
主要结局
Spanish-Complutense Verbal Learning Test (TAVEC)
时间窗: 30 minutes
The evaluator reads a 16-word shopping list in five different essays and in each of them the evaluated person must mention those words that he or she remembers. After 20 minutes, the subject is asked to remember them again.
Rey-Osterrieth Complex Figure Test (ROCFT)
时间窗: 10 minutes
The direct score (PD) in the copy of the Rey figure that would leave 50% of the population below is 30 points, while in the reproduction of the Rey figure from memory the PD that would leave 50% below of the population is 21 points.
Frontal assessment battery (FAB)
时间窗: 10 minutes
The maximum score to be obtained in this test is 18 points. To consider that the subject presents alterations in the frontal lobe and, therefore, altered executive functions, his score must be equal to or less than 11 points.
Barcelona test (BT)
时间窗: 5 minutes
In this test, the subject is considered to have a good categorical evocation when he is able to evoke more than 16 animals in 1 minute and a good verbal fluency when he is able to evoke more than 19 words beginning with "p" in 3 minutes.
Memory alteration test (M@T)
时间窗: 5-10 minutes
This cognitive test is evaluated on a maximum of 50 points. The optimal cut-off point for distinguishing mild cognitive impairment of the amnesiac type from subjective memory complaints is 37 points. The optimal cut-off point for Alzheimer's disease is 31 points.
Auto-Assessment Manikins (SAM)
时间窗: 5-10 minutes
This questionnaire measures the valence (liking/disliking depending on the emotion induced by scenes from different movies), the arousal (excitement caused by each of the movie scenes) and mastery or emotional control (self-perception of the control exerted on the environment and the emotion itself).
Mini-Mental State Examination (MMSE)
时间窗: 5-10 minutes
This test is evaluated on a maximum of 30 points. Participants with scores equal to or below 23 would be considered cognitively deficient.
Beck Depression Inventory-II (BDI-II)
时间窗: 5-10 minutes
In this test, a score of 0-13 indicates absence of depression, 14-19 mild depression, 20-28 moderate depression, and 29-63 severe depression.
Global Deterioration Scale (GDS)
时间窗: 30 minutes
This scale indicates seven possible stages: 1. Absence of Cognitive Deficit; 2. Very slight cognitive deficit; 3. Mild Cognitive Deficit; 4. Moderate cognitive deficit; 5. Moderately severe cognitive deficit; 6. Severe cognitive deficit; 7. Very severe cognitive deficit.
Positive and Negative Affect Scale (PANAS)
时间窗: 10 minutes
The final score of this scale is the sum of the 10 terms on the positive scale and the sum of the 10 terms on the negative scale, with the value assigned for the responses on the positive scale being positive and negative for the responses on the negative scale.
次要结局
未报告次要终点