Thoracic epidural anesthesia with ropivacaine: effects of age on neural blockade and cardiovascular parameters

Conditions: Medical conditions will not be investigated per se, however we will study the effect of standard thoracic epidural anesthesia on specific age groups undergoing lung surgery

Registration Number: EUCTR2009-010594-20-NL

Lead Sponsor: MC

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Authorised-recruitment may be ongoing or finished

Sex: All

Target Recruitment: Not specified

Inclusion Criteria

Male and female patient
ASA I-III
Patients undergoing thoracic surgery under thoracic epidural anesthesia

Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

Cardiac rhythm other than sinus rhythm
Diabetes mellitus
Infection of the skin in the area of the epidural site
A history of neurological diseases
A history of bleeding diathesis
Muscle diseases
Hypersensitive to local anesthetics
Pregnancy or lactation
Participation in a trial on investigational drugs within 3 months prior to the study

Study & Design

Study Type: Interventional clinical trial of medicinal product

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Main Objective: Effect of age on neural blockade and cardiovascular parameters following thoracic epidural administration of ropivacaine;Secondary Objective: to collect data in order to create a dose regimen for thoracic epidural anesthesia in the elderly;Primary end point(s): Time to initial onset of analgesia at the T3-T4 dermatomes<br>Time to initial onset of motor blockade<br>Time until maximum cephalad spread of analgesia<br>Time until maximum caudad spread of analgesia<br>Highest level of analgesia<br>Maximum numbers of segments blocked<br>Maximum score of motor block (Bromage scale and ESSAM score<br><br>systolic function of left and right ventricle<br>diastolic function of left ventricle<br>segmental wall motion score<br>Right atriala pressure<br>cardiac output<br>invasive blood pressure<br>

Secondary Outcome Measures