Atezolizumab Trial in Endometrial Cancer - AtTEnd
- Conditions
- Endometrial Cancer
- Interventions
- Registration Number
- NCT03603184
- Lead Sponsor
- Mario Negri Institute for Pharmacological Research
- Brief Summary
Atezolizumab is an engineered humanised monoclonal immunoglobulin G1 antibody that binds selectively to PD-L1 and prevents its interaction with PD-1 and B7-1.
In May 2016 atezolizumab was approved by the FDA for patients with locally advanced or metastatic urothelial carcinoma who have disease progression during or following any platinum-containing chemotherapy, or within 12 months of receiving chemotherapy before surgery (neoadjuvant) or after surgery (adjuvant); in October 2016 it was approved by the FDA for patients with metastatic non-small cell lung cancer (NSCLC) who have disease progression during or following platinum-containing chemotherapy, and have progressed on an appropriate FDA-approved targeted therapy if their tumor has EGFR or ALK gene abnormalities. Finally, in April 2017 atezolizumab was granted accelerated approval by FDA for the first-line treatment of patients with locally advanced or metastatic urothelial carcinoma who are not eligible for cisplatin chemotherapy. Combinations of atezolizumab with chemotherapeutic agents and/or targeted therapies were studied in different solid tumors such as melanoma, NSCLC, renal cell carcinoma and colorectal carcinoma. From these studies the AE profile of atezolizumab combinations were consistent with that of the individual agents.
Finally, preliminary results of a Phase Ia study of Atezolizumab (NCT01375842) monotherapy in relapsed endometrial cancer were reported as abstract at ASCO 2017. Fifteen patients were evaluated for safety and efficacy with a minimum follow-up of 11.2 months. No G4-5 related AEs occurred. Regarding efficacy ORR was 13% \[2/15\] by RECIST. Atezolizumab seemed to have a favorable safety profile, with durable clinical benefit in some patients. Further studies with atezolizumab are warranted given its promising results in advanced endometrial cancer and the limited efficacy of current treatment options.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 549
I-1. Newly diagnosed, histologically-confirmed with residual disease after surgery either measurable or evaluable, or inoperable stage III-IV endometrial carcinoma/carcinosarcoma, after diagnostic biopsy, and naïve to first line systemic anti-cancer treatment. Recurrent endometrial cancer patients if not yet treated for recurrent disease.
I-2. Eastern Cooperative Oncology Group (ECOG) performance status 0-2 I-3. Age ≥ 18 years I-4. Only one prior line of systemic platinum-based regimen is permitted if the platinum-free interval ≥ 6 months. Such prior line is the up-front/adjuvant treatment which can be concurrent chemoradiation or concurrent chemoradiation followed by chemotherapy or only chemotherapy.
I-5. Patients with history of primary breast cancer may be eligible provided they completed their definitive anticancer treatment more than 3 years ago and they remain breast cancer disease free prior to start of study treatment.
I-6. Previous pelvic and outside pelvis radiation is allowed if completed more than 6 weeks ago.
I-7. Signed informed consent and ability to comply with treatment and follow-up.
I-8. Representative FFPE tumor sample or, only if unfeasible, at least 20 unstained slides from initial surgery or from diagnostic biopsy, in case surgery was not performed, available and sent to central laboratory for Micro Satellite (MS) determination prior to randomization.
I-9. Patients must have normal organ and bone marrow function :
- Haemoglobin ≥ 10.0 g/dL.
- Absolute neutrophil count (ANC) ≥ 1.5 x 109/L.
- Platelet count ≥ 100 x 109/L.
- Total bilirubin ≤ 1.5 x institutional upper limit of normal (ULN).
- Aspartate aminotransferase /Serum Glutamic Oxaloacetic Transaminase (ASAT/SGOT)) and Alanine aminotransferase /Serum Glutamic Pyruvate Transaminase (ALAT/SGPT)) ≤ 2.5 x ULN, unless liver metastases are present in which case they must be ≤ 5 x ULN.
- Serum creatinine ≤ 1.5 x institutional ULN
E-1. Other malignancy within the last 5 years except: adequately treated non-melanoma skin cancer, curatively treated in situ cancer of the cervix, ductal carcinoma in situ (DCIS) of the breast. Patients with a history of localized malignancy diagnosed over 5 years ago may be eligible provided they completed their adjuvant systemic therapy prior to randomization and that the patient remains free of recurrent or metastatic disease.
E-2. Patients with uterine leiomyosarcoma . E-3. Major surgery within 4 weeks of starting study treatment or patients who have not completely recovered from the effects of any major surgery.
E-4. Previous allogeneic bone marrow transplant or previous solid organ transplantation.
E-5. Administration of other simultaneous chemotherapy drugs, any other anticancer therapy or anti-neoplastic hormonal therapy, or simultaneous radiotherapy during the trial treatment period (hormonal replacement therapy is permitted).
E-6. Prior treatment with CD137 agonists or immune checkpoint blockade therapies, anti-PD1, or anti-PDL1 therapeutic antibodies or anti-CTLA4 .
E-7. Treatment with systemic immunostimulatory agents (including but not limited to interferon-alpha (IFN-α) and interleukin-2 (IL-2) within 4 weeks or five half-lives of the drug (whichever is shorter) prior to Cycle 1, Day 1.
E-8. Treatment with systemic corticosteroids or other systemic immunosuppressive medications (including but not limited to prednisone, dexamethasone, cyclophosphamide, azathioprine, methotrexate, thalidomide, and anti-tumor necrosis factor [TNF] agents) within 2 weeks prior to Cycle 1, Day 1, or anticipated requirement for systemic immunosuppressive medications during the trial. However, please note that the use of inhaled corticosteroids for chronic obstructive pulmonary disease or for asthma is allowed, as well as the use of mineralocorticoids (e.g., fludrocortisones) and low-dose supplemental corticosteroids for adrenocortical insufficiency and for patients with orthostatic hypotension. The use of corticosteroids as premedication for paclitaxel-based regimen is allowed).
E-9. History of autoimmune disease, including but not limited to myasthenia gravis, myositis,autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, vascular thrombosis associated with anti-phospholipid syndrome, Wegener's granulomatosis, Sjögren's syndrome, Guillain-Barré syndrome, multiple sclerosis, vasculitis, or glomerulonephritis [please note: patients with a history of autoimmune hypothyroidism on a stable dose of thyroid replacement hormone are eligible; patients with controlled Type 1 diabetes mellitus on a stable insulin regimen are eligible; history of idiopathic pulmonary fibrosis (including pneumonitis), drug-induced pneumonitis, organizing pneumonia (i.e., bronchiolitis obliterans, cryptogenic organizing pneumonia) is permitted].
E-10. Immunocompromised patients, e.g., patients who are known to be serologically positive for human immunodeficiency virus (HIV).
E-11. Patients with active hepatitis B (defined as having a positive hepatitis B surface antigen [HBsAg] test at screening) or hepatitis C .
- Patients with past hepatitis B virus (HBV) infection or resolved HBV infection (defined as having a negative HBsAg test and a positive total hepatitis B core antibody [HBcAb]) are eligible only if hepatitis B virus (HBV) DNA is negative. The HBV DNA test will be performed only for patients who have a positive total HBcAb test.
- Patients positive for hepatitis C virus (HCV) antibody are eligible only if polymerase chain reaction (PCR) is negative for HCV RNA. The HCV RNA test will be performed only for patients who have a positive HCV antibody test.
E-12. Active tuberculosis (all patients will have tuberculin [PPD] skin test or Interferon-Gamma Releasing Assay [IGRA] done locally prior to inclusion to study) E-13. Signs or symptoms of infection within 2 weeks prior to Cycle 1, Day 1 E-14. Administration of a live, attenuated vaccine within 4 weeks prior to Cycle 1, Day 1 or anticipation that such a live attenuated vaccine will be required during the study. Influenza vaccination should be given during influenza season only (example approximately October to March in the Northern Hemisphere). Patients must not receive live, attenuated influenza vaccine.
E-15. Clinically significant (e.g. active) cardiovascular disease, including:
- Myocardial infarction or unstable angina within ≤ 6 months of randomization,
- New York Heart Association (NYHA) ≥ grade 2 congestive heart failure (CHF),
- Poorly controlled cardiac arrhythmia despite medication (patients with rate controlled atrial fibrillation are eligible),
- Peripheral vascular disease grade ≥ 3 (e.g. symptomatic and interfering with activities of daily living [ADL] requiring repair or revision) E-16. Resting ECG with QTc > 470 msec on 2 or more time points within a 24 hour period or family history of long QT syndrome.
E-17. History or clinical suspicion of brain metastases or spinal cord compression. CT/MRI of the brain is mandatory (within 4 weeks prior to randomization) in case of suspected brain metastases. Spinal MRI is mandatory (within 4 weeks prior to randomization) in any case of suspected central nervous system (CNS) involvement .
E-18. History or evidence upon neurological examination of central nervous system (CNS) disease, unless asymptomatic and adequately treated with standard medical therapy.
E-19. Evidence of any other disease, metabolic dysfunction, physical examination finding or laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug or puts the patient at high risk for treatment related complications.
E-20. Women of childbearing potential (<2 years after last menstruation) not willing to use highly-effective means of contraception.
E-21. Pregnant or lactating women. E-22. History of severe allergic, anaphylactic, or other hypersensitivity reactions to chimeric or humanized antibodies or fusion proteins.
E-23. Known hypersensitivity or allergy to biopharmaceuticals produced in Chinese hamster ovary cells or to any component of the atezolizumab formulation.
E-24. Known hypersensitivity reaction or allergy to drugs chemically related to carboplatin, paclitaxel, or their excipients that contraindicates the subject's participation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Control arm Placebos paclitaxel 175 mg/m2 + carboplatin AUC 5 or AUC 6 will be administered every 21 days for 6-8 cycles or PD. Placebo will be administered as I.V. infusion every 21 days until objective radiological disease progression as assessed by the investigator if they do not meet any other discontinuation criteria (patient refusal, toxicity). Patients who are clinically stable at initial RECIST v 1.1 - defined progression - should continue on treatment until the next imaging assessment that should be ≥4 weeks and no longer than 8 weeks later. Experimental arm Paclitaxel paclitaxel 175 mg/m2 + carboplatin AUC 5 or 6 will be administered every 21 days for 6-8 cycles or PD. Atezolizumab will be administered as I.V. infusion at a fixed dose of 1200 mg, every 21 days until objective radiological disease progression as assessed by the investigator if they do not meet any other discontinuation criteria (patient refusal, toxicity). Patients who are clinically stable at initial RECIST v 1.1 - defined progression - should continue on treatment until the next imaging assessment that should be ≥4 weeks and no longer than 8 weeks later. Experimental arm Atezolizumab paclitaxel 175 mg/m2 + carboplatin AUC 5 or 6 will be administered every 21 days for 6-8 cycles or PD. Atezolizumab will be administered as I.V. infusion at a fixed dose of 1200 mg, every 21 days until objective radiological disease progression as assessed by the investigator if they do not meet any other discontinuation criteria (patient refusal, toxicity). Patients who are clinically stable at initial RECIST v 1.1 - defined progression - should continue on treatment until the next imaging assessment that should be ≥4 weeks and no longer than 8 weeks later. Experimental arm Carboplatin paclitaxel 175 mg/m2 + carboplatin AUC 5 or 6 will be administered every 21 days for 6-8 cycles or PD. Atezolizumab will be administered as I.V. infusion at a fixed dose of 1200 mg, every 21 days until objective radiological disease progression as assessed by the investigator if they do not meet any other discontinuation criteria (patient refusal, toxicity). Patients who are clinically stable at initial RECIST v 1.1 - defined progression - should continue on treatment until the next imaging assessment that should be ≥4 weeks and no longer than 8 weeks later. Control arm Carboplatin paclitaxel 175 mg/m2 + carboplatin AUC 5 or AUC 6 will be administered every 21 days for 6-8 cycles or PD. Placebo will be administered as I.V. infusion every 21 days until objective radiological disease progression as assessed by the investigator if they do not meet any other discontinuation criteria (patient refusal, toxicity). Patients who are clinically stable at initial RECIST v 1.1 - defined progression - should continue on treatment until the next imaging assessment that should be ≥4 weeks and no longer than 8 weeks later. Control arm Paclitaxel paclitaxel 175 mg/m2 + carboplatin AUC 5 or AUC 6 will be administered every 21 days for 6-8 cycles or PD. Placebo will be administered as I.V. infusion every 21 days until objective radiological disease progression as assessed by the investigator if they do not meet any other discontinuation criteria (patient refusal, toxicity). Patients who are clinically stable at initial RECIST v 1.1 - defined progression - should continue on treatment until the next imaging assessment that should be ≥4 weeks and no longer than 8 weeks later.
- Primary Outcome Measures
Name Time Method PFS in the MSI Up to 18 months after the last patient enrolled PFS is defined as the time from randomization to the date of first progression or death
PFS Up to 18 months after the last patient enrolled PFS is defined as the time from randomization to the date of first progression or death from any cause, whichever comes first.
Progression will be established as the radiological disease progression according to RECIST 1.1 or death from any cause, whichever occurs first.OS Up to two years after the last patient enrolled OS is defined as the time from randomization until the date of death from any cause.
- Secondary Outcome Measures
Name Time Method Objective response rate Up to three years after the last patient enrolled Objective Response Rate (ORR), defined as the percentage of patients with an objective response as determined by RECIST 1.1
Safety: Maximum toxicity grade Up to 30 days after the end of treatment Maximum toxicity grade experienced by each patient, for each toxicity, according to NCI-CTCAE v. 4.03
Duration of response Up to two years after the last patient enrolled Duration of response, defined as the time from the date of first documentation of response (complete response (CR) or partial response (PR), whichever occurs first) to the date of documented PD or death
Safety: Number of patients experiencing grade 3-4 toxicity for each toxicity Up to 30 days after the end of treatment Number of patients experiencing grade 3-4 toxicity for each toxicity according to NCI-CTCAE v. 4.03
Safety: Type, frequency and nature of SAEs Up to 30 days after the end of treatment Type, frequency and nature of SAEs, according to NCI-CTCAE v. 4.03
Safety: Number of patients with at least a SAE Up to 30 days after the end of treatment Number of patients with at least a SAE according to NCI-CTCAE v. 4.03
Safety: Number of patients with at least a SUSAR Up to two years after the last patient enrolled Number of patients with at least a SUSAR, according to NCI-CTCAE v. 4.03
Quality of life: QLQ-EN24 questionnaire Up to two years after the last patient enrolled Mean changes from the baseline score in quality of life by cycle and between treatment arms.
Compliance: Number of administered cycles Up to two year after the last patient enrolled Number of administered cycles
Compliance: Dose intensity Up to two year after the last patient enrolled Entire dose administered during treatment
Quality of life: GP5 item Up to two years after the last patient enrolled Proportion of patients reporting each response option at each assessment timepoint by treatment arm for item GP5 from the FACT G instrument.
Compliance: Reasons for discontinuation and treatment modification Up to two year after the last patient enrolled Number of patients for each reasons
Safety: Number of patients with at least a SADR Up to two years after the last patient enrolled Number of patients with at least a SADR, according to NCI-CTCAE v. 4.03
Quality of life: EORTC QLQ-C30 questionnaire Up to two years after the last patient enrolled Mean changes from the baseline scores in quality of life by cycle and between treatment arms.
Trial Locations
- Locations (90)
Tohoku University Hospital
🇯🇵Miyagi, Japan
Universitätsspital
🇨🇭Zürich, Switzerland
Inselspital
🇨🇭Bern, Switzerland
Frauenfeld
🇨🇭Münsterlingen, Switzerland
Medical University of Innsbruck
🇦🇹Innsbruck, Austria
Border Medical Oncology Research Unit
🇦🇺Albury, Australia
Pindara Private Hospital
🇦🇺Benowa, Australia
Royal Hobart Hospital
🇦🇺Hobart, Australia
Royal Adelaide hospital
🇦🇺Adelaide, Australia
Gosford Hospital
🇦🇺Gosford, Australia
Calvary Mater Newcastle
🇦🇺Waratah, Australia
Icon Cancer Centre
🇦🇺Auchenflower, Australia
Klinikum der Ludwig-Maximilians-Universität München (LMU)
🇩🇪Muenchen, Germany
Box Hill Hospital
🇦🇺Box Hill, Australia
Frankston Hospital
🇦🇺Frankston, Australia
Royal Brisbane and Women's Hospital
🇦🇺Herston, Australia
Liverpool Hospital
🇦🇺Liverpool, Australia
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Gachon University Gil Medical Center
🇰🇷Incheon, Korea, Republic of
Policlinico S. Orsola Malpighi
🇮🇹Bologna, Italy
Istituto Europeo di Oncologia
🇮🇹Milan, Italy
Ospedale San Gerardo
🇮🇹Monza, Italy
Istituto Oncologico Veneto (IOV)
🇮🇹Padova, Italy
AO Arcispedale Santa Maria Nuova
🇮🇹Reggio Emilia, Italy
Ospedale SS Trinità
🇮🇹Sora, Italy
AOU Città della Salute e della Scienza di Torino - Ospedale Sant'Anna
🇮🇹Torino, Italy
Hospital De Sant Pau I La Santa Creu
🇪🇸Barcelona, Spain
Royal Devon & Exeter Hospital
🇬🇧Exeter, United Kingdom
Beatson West of Scotland Cancer Centre, Gartnavel General Hospital
🇬🇧Glasgow, United Kingdom
Institut Català d'Oncologia (ICO), L'Hospitalet- Hospital Duran I Reynals
🇪🇸Hospitalet de Llobregat, Spain
Hospital 12 de Octubre
🇪🇸Madrid, Spain
Hospital Universitario Central de Asturias
🇪🇸Oviedo, Spain
Hospital Universitario Miguel Servet Zaragoza
🇪🇸Zaragoza, Spain
Chang Gung Memorial Hospital-Linkou
🇨🇳Taoyuan City, Taiwan
Hospital Clínico Universitario Santiago de Compostela
🇪🇸Santiago De Compostela, Spain
MD Anderson Cancer Center
🇪🇸Madrid, Spain
Velindre Cancer Centre
🇬🇧Glasgow, United Kingdom
The Christie NHS Foundation Trust
🇬🇧Manchester, United Kingdom
AOU Pisana
🇮🇹Pisa, Italy
AO Ordine Mauriziano
🇮🇹Torino, Italy
P.O Sant'Andrea Vercelli
🇮🇹Vercelli, Italy
Imperial College Healthcare NHS Trust
🇬🇧London, United Kingdom
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Seoul St. Mary's Hospital
🇰🇷Seoul, Korea, Republic of
Severance Hospital
🇰🇷Seoul, Korea, Republic of
Derriford Hospital
🇬🇧Plymouth, United Kingdom
Northern Cancer Institute
🇦🇺Saint Leonards, Australia
Wollongong Hospital
🇦🇺Wollongong, Australia
Medizinische Universitaet Graz - Universitätsklinik für Frauenheilkunde und Geburtshilfe
🇦🇹Graz, Austria
Darling Downs Hospital and Health Service - Toowoomba Hospital
🇦🇺Toowoomba, Australia
UniversitätsKlinikum Heidelberg
🇩🇪Mannheim, Germany
Charité Universitätsmedizin Berlin
🇩🇪Berlin, Germany
Kliniken Essen Mitte
🇩🇪Essen, Germany
Azienda Sanitaria dell'Alto Adige
🇮🇹Bolzano, Italy
ASST degli Spedali Civili di Brescia
🇮🇹Brescia, Italy
AO SS Antonio e Biagio e Cesare Arrigo
🇮🇹Alessandria, Italy
Fondazione Poliambulanza
🇮🇹Brescia, Italy
AOU Cagliari, Policlinico Universitario
🇮🇹Cagliari, Italy
AOU Careggi
🇮🇹Firenze, Italy
ASST di Lecco
🇮🇹Lecco, Italy
Ospedale San Luca
🇮🇹Lucca, Italy
AOU di Parma
🇮🇹Parma, Italy
Ospedale di Sondrio ASST Valtellina e Alto Lario
🇮🇹Sondrio, Italy
Ausl Romagna
🇮🇹Rimini, Italy
Policlinico Umberto I, Università di Roma "La Sapienza"
🇮🇹Roma, Italy
Hirosaki University Hospital
🇯🇵Aomori, Japan
National Cancer Center Hospital East
🇯🇵Chiba, Japan
Shikoku Cancer Center
🇯🇵Ehime, Japan
Seoul National University Bundang Hospital
🇰🇷Gyeonggi-do, Korea, Republic of
Keimyung University Dongsan Medical Center
🇰🇷Daegu, Korea, Republic of
Keio University Hospital
🇯🇵Tokyo, Japan
Ilsan Cha Medical Center
🇰🇷Gyeonggi-do, Korea, Republic of
Gangnam Severance Hospital
🇰🇷Seoul, Korea, Republic of
Konkuk University Medical Center
🇰🇷Seoul, Korea, Republic of
Hospital Universitario Vall d´Hebron Institute of Oncology (VHIO)
🇪🇸Barcelona, Spain
Auckland city Hospital
🇳🇿Auckland, New Zealand
Institut Català d'Oncologia (ICO) Girona
🇪🇸Girona, Spain
Hospital Universitario La Paz
🇪🇸Madrid, Spain
Kantonsspital
🇨🇭Winterthur, Switzerland
Chang Gung Memorial Hospital-Kaohsiung
🇨🇳Kaohsiung City, Taiwan
IOSI
🇨🇭Bellinzona, Switzerland
Royal Marsden Hospital
🇬🇧London, United Kingdom
Royal Derby Hospital
🇬🇧Derby, United Kingdom
NUHT - Nottingham University Hospital NHS Trust
🇬🇧Nottingham, United Kingdom
Kurume University Hospital
🇯🇵Fukuoka, Japan
Hokkaido University Hospital
🇯🇵Hokkaido, Japan
Niigata University Medical＆Dental Hospital
🇯🇵Niigata, Japan
Osaka University Hospital
🇯🇵Osaka, Japan
Shizuoka Cancer Center
🇯🇵Shizuoka, Japan
St Bartholomew's Hospital
🇬🇧London, United Kingdom