Clinical trial on scarring alopecia (where hair roots are permanently lost because of scarring)

Not Applicable

• Conditions: Health Condition 1: L669- Cicatricial alopecia, unspecified

• Registration Number: CTRI/2022/11/047658
• Lead Sponsor: Indian association of dermatologist venereologist and leprologist

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 January 2023

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

All cases of acquired cicatricial alopecia affecting any body part will be included

who are willing to sign informed consent form, in case of minor, parent will have to

sign informed consent form.

Exclusion Criteria

1. Patients who are not willing to sign informed consent form

2. Patients with non scarring alopecia

3. Patients with traumatic cicatricial alopecia (Mechanical injury, Thermal

injury, Electrical burns, Traction alopecia (persistent), Trichotillomania

(persistent), Factitious injury, etc )

4. Patients with congenital cicatricial alopecia (Aplasia cutis, Focal dermal

hypoplasia, Dystrophic epidermolysis bullosa, Incontinentia pigmenti,

Conradi syndrome, Keratosis pilaris atrophicans faciei, Keratosis follicularis

spinulosa decalvans, Darierâ??s disease, Porokeratosis of Mibelli, Epidermal

nevus, Lamellar ichthyosis, Marieâ??Unna syndrome, Follicular hamartoma

syndrome, Polyostotic fibrous dysplasia, Hallermannâ??Streiff syndrome,

Incontinentia pigmenti, Rappâ??Hodgkin syndrome)

5. Patients with secondary cicatricial alopecia due to infections.

6. Patients with soft tissue and appendageal tumours which might affect

expression of CD34.

7. Patients with haematological disorders and malignancy.

8. Cutaneous malignancy involving head and neck.

9. Patients with vascular tumours

10.Malignancy induced primary or secondary cicatricial alopecia except

Alopecia Mucinosa

11.Patients with history of previous scalp procedure

12.Patients with hypertrophic scars or keloid in head and neck area except acne

keloidalis nuchae

13.Pregnant and lactating females

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To estimate the correlation between clinical, trichoscopic and <br/ ><br>histopathological findings and immunohistochemistry expression of <br/ ><br>hair follicle stem cell marker CD34 with duration of disease in patients <br/ ><br>of cicatricial alopecia.Timepoint: It is a cross sectional single visit study on day 0.

Secondary Outcome Measures

Name	Time	Method
To estimate hospital-based prevalence of cicatricial alopecia. <br/ ><br>â?? To estimate correlation between clinical, trichoscopic and <br/ ><br>histopathological parameters in end stage cicatricial alopecia where <br/ ><br>there are no symptoms and histopathology reveals no inflammation.Timepoint: It is a cross sectional single visit study on day 0.