Comparison of Volume Controlled Ventilation With 1:1 Inspiratory to Expiratory Ratio and Autoflow-volume Controlled Ventilation in Robot-assisted Laparoscopic Radical Prostatectomy With Steep Trendelenburg Position and Pneumoperitoneum

Not Applicable

Completed

• Conditions: Robot Assisted Laparoscopic Prostatectomy
• Interventions: Procedure: ventilation strategy 2; Procedure: ventilation strategy 1

• Registration Number: NCT03202953
• Lead Sponsor: Yonsei University

Brief Summary

The purpose of this study is to compare the 1: 1 I: E ratio VCV and the autoflow VCV in patients undergoing robot assisted laparoscopic prostatectomy

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-06-26
• Study First Submitted QC: 2017-06-27
• Study First Posted: 2017-06-29
• Study Start: 2017-07-04
• Primary Completion: 2018-01-24
• Study Completion: 2018-01-24
• Status Verified: 2018-05
• Last Update Submitted: 2018-05-17
• Last Update Posted: 2018-05-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 78

Inclusion Criteria

1. adult (20-80 years old)
2. patients undergoing robot assisted laparoscopic prostatectomy

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Exclusion Criteria

1. history of COPD
2. decreased heart function (EF <50%)
3. BMI>30
4. patients who cannot read the consent form (e.g., blind, foreigner)

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
autoflow VCV (Group A)	ventilation strategy 2	autoflow volume-controlled ventilation After trendelenburg position, Tidal volume : 8ml/kg, inspiration:expiration ratio = 1:2, FiO2 = 0.5, maintain end tidal CO2 around 40±5 mmHg. Positive end expiratory pressure will not used.
1:1 I:E ratio VCV (Group I)	ventilation strategy 1	volume controlled ventilation with 1:1 inspiratory to expiratory ratio After trendelenburg position, Tidal volume : 8ml/kg, inspiration:expiration ratio = 1:1, FiO2 = 0.5, maintain end tidal CO2 around 40±5 mmHg. Positive end expiratory pressure will not used.

Primary Outcome Measures

Name	Time	Method
PaO2	30 minutes after trendelenburg position	PaO2 analyzed by arterial blood gas analysis

Secondary Outcome Measures

Name	Time	Method
Arterial blood gas analysis	10 minutes after induction (T1), 30 minutes after trendelenburg position (T2), 60 minutes after trendelenburg position (T3), 10 minutes after supine position (T4)	pH, SaO2, Base excess
PaO2	10 minutes after induction (T1), 30 minutes after trendelenburg position (T2), 60 minutes after trendelenburg position (T3), 10 minutes after supine position (T4)
End tidal CO2	10 minutes after induction (T1), 30 minutes after trendelenburg position (T2), 60 minutes after trendelenburg position (T3), 10 minutes after supine position (T4)
peak airway pressure	10 minutes after induction (T1), 30 minutes after trendelenburg position (T2), 60 minutes after trendelenburg position (T3), 10 minutes after supine position (T4)
blood pressure	10 minutes after induction (T1), 30 minutes after trendelenburg position (T2), 60 minutes after trendelenburg position (T3), 10 minutes after supine position (T4)

Trial Locations

Locations (1)

Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine; 🇰🇷 Seoul, Korea, Republic of