Study to evaluate the effect of intravenous low dose Dexmedetomidine on blunting haemodynamic responses to laryngoscopy and tracheal intubation in patients undergoing surgery under general anaesthesia

Recruiting

• Conditions: Any patients electively posted for general anaesthesia with endotracheal intubation

• Registration Number: CTRI/2017/06/008885
• Lead Sponsor: University College of Medical Sciences

Brief Summary

SUMMARY

Laryngoscopy and tracheal intubation cause sympathetic stimulation in human body which will be easily tolerated by healthy people. The haemodynamic responses caused by sympathetic stimulation will be significant in unhealthy subjects. So many drugs have been used for studies for blunting those responses like lignocaine, nalbuphine, clonidine etc. Dexmedetomidine is also one of those drugs which have been studied for these purpose by many authors. Effect of the drug in blunting the haemodynamic responses was found to be dose dependant. But in high doses significant incidences of adverse effects was documented.



The cited study is planned as a randomised double blinded controlled study using low dose ( 0.5 mcg/kg ) Dexmedetomidine to blunt the haemodynamic responses to laryngoscopy and tracheal intubation. The drug/placebo will be infused to the patients in 100ml Normal saline , 10 minutes before induction of general anaesthesia. Haemodynamic parameters will be noted in regular intervals perioperatively. The response in haemodynamic parameters will be compared and analysed afterwards by unpaired t test and repeated measures by ANOVA followed by Tukey’s test. Incidence of side effects will be also noted. Qualitative meausres will be analysed by chi square test. P value less than 0.05 will be considered significant

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2017-05-29
• Study Start: 2017-10-01

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Elective surgery under general anaesthesia with endotracheal intubation ASA grade 1 patients having Mallampatti grade 1 airway.

Exclusion Criteria

Anticipated difficult airway History of cardiovascular, renal, respiratory, endocrine and neuronal disoders Pregnant and lactating women Patients taking any drugs affecting haemodynamic parameters.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference in Systolic Blood Pressure following laryngoscopy and tracheal intubation in two groups.	1, 3, 5, 7 and 10 minutes following laryngoscopy and tracheal intubation.

Trial Locations

Locations (1)

University College of Medical Sciences and GTB hospital; 🇮🇳 East, DELHI, India

University College of Medical Sciences and GTB hospital

🇮🇳East, DELHI, India

Dr Mahendra Kumar

Principal investigator

09868399709

mahendramohit@yahoo.com