Impact of Peripheral Nerve Blockade on Outcomes After Total Knee Replacement
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pain
- Sponsor
- Ottawa Hospital Research Institute
- Enrollment
- 178214
- Locations
- 1
- Primary Endpoint
- Hospital length of stay
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
Pain is common after knee replacement surgery and can impact a variety of patient outcomes. Peripheral nerve blocks provide improved pain control and may improve function. However, their impact on other outcomes is poorly described. Therefore, this comparative effectiveness study will estimate the independent association between nerve blocks and health outcomes after knee replacement surgery.
Detailed Description
This retrospective, population-based cohort study will evaluate the comparative effectiveness of peripheral nerve blocks on patient and health system outcomes after elective total knee replacement surgery. The investigators will develop a non-parsimonious propensity score to control for potential indication bias and confounding in this observational study. Using the propensity score the investigators will match patients who receive a peripheral nerve block to a patient who did not to estimate the independent association of peripheral nerve blocks with our study outcomes.
Investigators
Dan McIsaac
Associate Scientist
Ottawa Hospital Research Institute
Eligibility Criteria
Inclusion Criteria
- •first primary total knee replacement during the study period
Exclusion Criteria
- •Revision arthroplasty
Outcomes
Primary Outcomes
Hospital length of stay
Time Frame: Day of surgery to day of discharge, or up to 365 days, whichever comes first
Determined from the Canadian Institute for Health Information Discharge Abstract Database record for the index hospitalization
Secondary Outcomes
- Hospital readmission(The outcome ascertainment window starts on the day of discharge and extends up to 30 days after surgery. Any readmission in this time period will be considered an event.)
- In-hospital fall(hospital admission)
- Emergency department visit(The outcome ascertainment window starts on the day of discharge and extends up to 30 days after surgery. Any emergency department visit in this time period will be considered an event.)