Impact of Peripheral Nerve Blockade on Outcomes After Total Knee Replacement
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 178,214
- 试验地点
- 1
- 主要终点
- Hospital length of stay
研究概览
简要总结
Pain is common after knee replacement surgery and can impact a variety of patient outcomes. Peripheral nerve blocks provide improved pain control and may improve function. However, their impact on other outcomes is poorly described. Therefore, this comparative effectiveness study will estimate the independent association between nerve blocks and health outcomes after knee replacement surgery.
详细描述
This retrospective, population-based cohort study will evaluate the comparative effectiveness of peripheral nerve blocks on patient and health system outcomes after elective total knee replacement surgery.
The investigators will develop a non-parsimonious propensity score to control for potential indication bias and confounding in this observational study. Using the propensity score the investigators will match patients who receive a peripheral nerve block to a patient who did not to estimate the independent association of peripheral nerve blocks with our study outcomes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •first primary total knee replacement during the study period
排除标准
- •Revision arthroplasty
结局指标
主要结局
Hospital length of stay
时间窗: Day of surgery to day of discharge, or up to 365 days, whichever comes first
Determined from the Canadian Institute for Health Information Discharge Abstract Database record for the index hospitalization
次要结局
- Hospital readmission(The outcome ascertainment window starts on the day of discharge and extends up to 30 days after surgery. Any readmission in this time period will be considered an event.)
- In-hospital fall(hospital admission)
- Emergency department visit(The outcome ascertainment window starts on the day of discharge and extends up to 30 days after surgery. Any emergency department visit in this time period will be considered an event.)
研究者
Dan McIsaac
Associate Scientist
Ottawa Hospital Research Institute